Description

[D-Pro2, D-Trp7,9]-Substance P CAS NO 80434-86-2 is a synthetic, biologically active peptide analog of the neuropeptide Substance P, designed with specific D-amino acid substitutions to enhance its stability and modulate its receptor interactions. This compound is a critical research tool for investigating neurokinin-1 (NK1) receptor pathways and their roles in pain transmission, inflammation, and various central nervous system processes. It is primarily utilized by pharmaceutical researchers, academic institutions, and biotechnology companies engaged in neuroscience, pharmacology, and drug discovery programs.

Application

• Neuroscience Research: As a potent and selective NK1 receptor antagonist for studying pain signaling, neuroinflammation, and behavioral responses.
• Pharmacological Studies: Used in in vitro and in vivo models to elucidate the physiological and pathophysiological roles of Substance P.
• Drug Discovery & Development: Serves as a reference standard and a lead compound for developing novel therapeutics targeting neurokinin receptors for conditions like migraine, depression, and emesis.
• Biochemical Assays: Employed in receptor binding assays, functional cellular assays, and signal transduction studies to characterize compound activity and selectivity.
• Academic & Clinical Research: Supports fundamental research into the mechanisms of nociception, stress responses, and immune-neural interactions.

Basic Information

Product Name	[D-Pro2, D-Trp7,9]-Substance P
CAS No.	80434-86-2
Molecular Formula	C63H88N18O13S
Molecular Weight	1345.6 g/mol
Synonyms	[D-Pro2, D-Trp7,9]-SP; [D-Pro2, D-Trp7,9]-Substance P (1-11); Arg-Pro-Lys-Pro-D-Pro-Gln-Phe-D-Trp-Gly-D-Trp-Met-NH2; [D-Pro2, D-Trp7,9]-Substance P (human, mouse, rat); Neurokinin-1 Receptor Antagonist; SP Analogue; D-Pro2, D-Trp7,9-Substance P
EINECS	Contact for details

Quality Control

Every batch of [D-Pro2, D-Trp7,9]-Substance P is manufactured and analyzed under strict quality management systems to ensure the highest standards of purity and consistency for research applications. Our products undergo rigorous quality testing, including advanced chromatographic and spectroscopic methods, to ensure compliance with industry standards. Certificates of Analysis (COA) detailing purity, identity, and other critical parameters are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This hygroscopic (moisture-sensitive) peptide should be kept dry and is recommended for long-term storage as a lyophilized powder. Allow the vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Mass spectrum consistent with theoretical molecular weight
Purity (HPLC)	≥ 95% (Area Percent)
Assay (Peptide Content)	≥ 80% (by weight)
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC)	≤ 10.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.