Description

Complement Factor B From Human Serum is a high-purity glycoprotein component of the alternative complement pathway, essential for immune system function. This critical reagent is vital for research and diagnostic applications requiring a reliable and well-characterized human protein source. It is primarily utilized by biotechnology firms, clinical research organizations, and in vitro diagnostic (IVD) manufacturers for applications in immunology, biomarker discovery, and assay development.

Application

• Immunological Research: Fundamental studies of the alternative complement pathway, activation mechanisms, and host-pathogen interactions.
• Diagnostic Assay Development: A key component in the production of ELISA kits, lateral flow assays, and other immunoassays for detecting complement-related disorders.
• Biomarker Standardization: Serves as a critical reference standard and calibrator for quantifying Factor B levels in clinical samples.
• Quality Control in Biologics: Used in QC testing for pharmaceuticals to assess complement activation potential.
• Cell Culture & In Vitro Studies: Supports research into inflammatory diseases, autoimmune conditions, and therapeutic antibody characterization.

Basic Information

Product Name	Complement Factor B From Human Serum
CAS No.	80295-62-1
Molecular Formula	Contact for details
Molecular Weight	~93 kDa (Glycoprotein)
Synonyms	Factor B; C3 Proactivator; Glycine-rich Beta Glycoprotein (GBG); Properdin Factor B; Complement Factor B; Bf; CFB; C3/C5 Convertase; PBF2; H2-Bf
EINECS	Contact for details

Quality Control

Our Complement Factor B From Human Serum is sourced and processed under stringent controls to ensure batch-to-batch consistency and high biological activity. Each lot undergoes rigorous quality testing, including purity assessment, functional activity assays, and screening for contaminants. Certificates of Analysis (COA) detailing specifications such as purity (by SDS-PAGE), functional activity, endotoxin levels, and sterility are available upon request.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below. Avoid repeated freeze-thaw cycles. This product is hygroscopic (moisture-sensitive); allow the vial to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder or clear solution
Identification (Immunoassay)	Positive for Human Factor B
Purity (SDS-PAGE)	> 95%
Functional Activity (Hemolytic Assay)	Contact for details
Endotoxin	< 1.0 EU/mg
Sterility (Membrane Filtration)	Sterile
Solubility	Soluble in water or specified buffer

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.