Description

Complement C1S, Human, Activated, Two-Chain Form is a highly purified, enzymatically active serine protease component of the classical complement pathway. This activated form is critical for research and development in immunology, as it plays a central role in initiating the complement cascade, a key effector mechanism of the innate immune system. It is essential for life science researchers, diagnostic manufacturers, and pharmaceutical developers working on inflammatory diseases, autoimmune disorders, and complement-targeted therapeutics.

Application

• Biomedical Research: Used as a key reagent to study the activation, regulation, and biological functions of the classical complement pathway in vitro.
• Diagnostic Development: Serves as a critical component or standard in immunoassays and kits designed to measure complement activity or deficiencies.
• Drug Discovery & Screening: Employed in high-throughput screening (HTS) platforms to identify and validate novel inhibitors of the C1 complex for therapeutic applications.
• Biomarker Studies: Utilized in proteomic and biochemical studies to investigate complement activation profiles associated with specific disease states.
• Quality Control: Acts as a reference standard for the quality assurance of other complement-related reagents and biological products.
• Enzymology Studies: Provides a model system for studying serine protease kinetics, specificity, and inhibition mechanisms.

Basic Information

Product Name	Complement C1S, Human, Activated, Two-Chain Form
CAS No.	80295-35-8
Molecular Formula	Contact for details
Molecular Weight	~83 kDa (Two-chain form)
Synonyms	Activated Complement C1s Subcomponent; Complement 1s Esterase; C1 Esterase; C1s Serine Protease; EC 3.4.21.42; Complement Component 1s; Human C1s; Activated C1s
EINECS	Contact for details

Quality Control

Our Complement C1S, Human, Activated, Two-Chain Form is manufactured under stringent conditions to ensure high biological activity and purity, suitable for research and diagnostic applications. Each lot is rigorously tested for functional activity, purity by SDS-PAGE, and the absence of contaminating proteases. Certificates of Analysis (COA) detailing specific purity, activity (U/mg), and analytical data are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C to -70°C in small aliquots to avoid repeated freeze-thaw cycles. This product is hygroscopic (moisture-sensitive) and strictly light-sensitive (protect from all light exposure). For long-term stability, keep desiccated.

Specification

Item	Specification
Appearance	Lyophilized powder or clear solution
Purity (SDS-PAGE)	> 95%
Specific Activity	> 50 U/mg protein
Protein Concentration	Contact for details
Buffer Composition	Tris, NaCl, Glycerol (if in solution)
Endotoxin Level	< 1.0 EU/μg
Functional Activity	Confirmed by cleavage of synthetic substrate (e.g., C1s esterase assay)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.