Description

2-(4-Nitro-Phenyl)-Ethanesulfonyl Chloride is a specialized sulfonyl chloride derivative, a key reactive intermediate in advanced organic synthesis. Its value lies in its ability to act as a versatile electrophile for introducing the 2-(4-nitrophenyl)ethanesulfonyl moiety, a functional group of significant interest in medicinal chemistry and materials science. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries developing novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of potential drug candidates, particularly in the development of enzyme inhibitors and receptor modulators.
• Agrochemical Synthesis: Used in the research and production of novel herbicides, fungicides, and plant growth regulators.
• Functional Material Precursor: Serves as a monomer or cross-linking agent in the creation of specialty polymers and advanced materials with specific sulfonyl-based properties.
• Chemical Biology Probe Development: Employed in the design and synthesis of activity-based probes (ABPs) for studying enzyme function and target engagement.
• Peptide and Protein Modification: Utilized for selective sulfonylation reactions to modify amino acid side chains, aiding in bioconjugation and structure-activity relationship (SAR) studies.
• Dye and Pigment Intermediate: Acts as a key intermediate in the synthesis of certain azo dyes and high-performance pigments.

Basic Information

Product Name	2-(4-Nitro-Phenyl)-Ethanesulfonyl Chloride
CAS No.	80259-15-0
Molecular Formula	C8H8ClNO4S
Molecular Weight	249.67 g/mol
Synonyms	2-(4-Nitrophenyl)ethanesulfonyl chloride; 4-Nitrobenzenesulfonyl chloride, 2-chloroethyl-; 2-(4-Nitrophenyl)ethanesulfonic acid chloride; 2-(p-Nitrophenyl)ethanesulfonyl chloride; 4-Nitro-α-toluenesulfonyl chloride; 1-(2-Chloroethylsulfonyl)-4-nitrobenzene; (4-Nitrophenyl)methanesulfonyl chloride, 2-chloro-; p-Nitrophenylethanesulfonyl chloride
EINECS	Contact for details

Quality Control

Our 2-(4-Nitro-Phenyl)-Ethanesulfonyl Chloride is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity suitable for research and commercial synthesis. We provide comprehensive analytical data, including HPLC purity, identity confirmation (IR, NMR), and impurity profiling. A Certificate of Analysis (COA) is supplied with each batch to guarantee compliance with your specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic and moisture-sensitive nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent decomposition. Keep away from strong bases, oxidizers, and moisture.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.