Description

Pipequaline Hydrochloride (CAS NO 80221-58-5) is a high-purity pharmaceutical intermediate and research chemical of significant interest in neuropharmacology. Its primary value lies in its well-characterized activity as a non-opioid analgesic and anxiolytic agent, making it a critical compound for advanced research and development. This product is essential for pharmaceutical R&D laboratories, academic institutions, and chemical suppliers serving the life sciences sector, where precise chemical structure and purity are paramount for experimental integrity and regulatory compliance.

Application

• Pharmaceutical Research & Development: Serves as a key intermediate or reference standard in the synthesis and study of novel central nervous system (CNS) active compounds.
• Neuropharmacological Studies: Used as a research tool to investigate mechanisms of analgesia, anxiety, and related neurological pathways in preclinical models.
• Analytical Reference Standard: Employed in quality control laboratories for method development, validation, and impurity profiling via HPLC, GC-MS, or NMR.
• Academic & Institutional Research: Utilized in university and government labs for fundamental research into neurotransmitter systems and receptor binding studies.
• Chemical Synthesis: Acts as a building block for medicinal chemists exploring structure-activity relationships (SAR) in the design of new therapeutic agents.
• Biotech & Contract Research Organizations (CROs): Supplied to organizations conducting outsourced drug discovery and safety pharmacology testing.

Basic Information

Product Name	Pipequaline Hydrochloride
CAS No.	80221-58-5
Molecular Formula	C₁₉H₂₀N₂O•HCl
Molecular Weight	328.84 g/mol
Synonyms	Pipequaline HCl; PK 8165; 2-Phenyl-3-[1-(2-phenylethyl)-4-piperidinyl]-4(3H)-quinazolinone hydrochloride; 4(3H)-Quinazolinone, 2-phenyl-3-[1-(2-phenylethyl)-4-piperidinyl]-, monohydrochloride; PK-8165; PK 8165 HCl; Benzodiazepine receptor partial agonist (PK 8165)
EINECS	Contact for details

Quality Control

Our Pipequaline Hydrochloride is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research applications. Each lot undergoes comprehensive analytical testing, including identification (IR, NMR), purity assay (HPLC), and control of related substances and residual solvents. A Certificate of Analysis (COA) detailing all test results and specifications is provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after each use to prevent degradation from atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.