Description

For-Met-Leu-Phe-Phe-Oh is a synthetic pentapeptide with the sequence formyl-methionyl-leucyl-phenylalanyl-phenylalanine. This compound is a well-characterized biochemical tool, primarily recognized for its role as a potent synthetic analog of bacterial chemotactic peptides. It is essential for researchers in immunology and cell biology studying neutrophil and macrophage activation, chemotaxis, and the N-formyl peptide receptor (FPR) signaling pathways. This high-purity peptide is critical for pharmaceutical R&D, academic research, and diagnostic assay development.

Application

• Biochemical Research: A standard ligand for studying the N-formyl peptide receptor (FPR1 and FPR2) family and associated intracellular signaling cascades.
• Immunology Studies: Used to induce and measure neutrophil chemotaxis, degranulation, and superoxide anion production in vitro.
• Inflammation Models: Employed to establish experimental models of acute inflammation and to screen potential anti-inflammatory compounds.
• Cell Biology: A key reagent for investigating leukocyte migration, phagocytosis, and immune cell activation mechanisms.
• Pharmaceutical Development: Serves as a reference standard and tool compound in the discovery of drugs targeting formyl peptide receptors for inflammatory and autoimmune diseases.
• Diagnostic Assays: Used in the development of assays to monitor receptor expression and function in clinical research samples.

Basic Information

Product Name	For-Met-Leu-Phe-Phe-Oh
CAS No.	80180-63-8
Molecular Formula	C38H49N5O7S
Molecular Weight	719.90 g/mol
Synonyms	N-Formyl-Met-Leu-Phe; fMLP; fMet-Leu-Phe; N-Formylmethionyl-leucyl-phenylalanine; Chemotactic Peptide fMLP; Formyl-Met-Leu-Phe; Formylmethionylleucylphenylalanine; N-Formyl-MLF
EINECS	Contact for details

Quality Control

Every batch of For-Met-Leu-Phe-Phe-Oh is manufactured under strict quality management systems and undergoes comprehensive analytical testing to ensure identity, purity, and consistency. Our products are suitable for critical research applications, with specifications typically meeting or exceeding ≥95% purity (by HPLC). Certificates of Analysis (COA) detailing batch-specific results for assay, related substances, and residual solvents are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Single Impurity (HPLC)	≤ 1.0%
Water Content (KF)	≤ 5.0%
Peptide Content	≥ 80.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.