Description

Lhrh, Ac-Dehydro-Pro(1)-4-Cl-Phe(2)-Trp(3,6)- CAS NO 80152-22-3 is a synthetic peptide analog of Luteinizing Hormone-Releasing Hormone (LHRH), featuring specific amino acid modifications including a dehydroproline and a chlorinated phenylalanine residue. This engineered structure is critical for enhancing metabolic stability and receptor binding affinity, making it a valuable research-grade biochemical tool. It is primarily utilized by pharmaceutical R&D departments, biotechnology firms, and academic research laboratories focused on endocrinology, oncology, and peptide therapeutics development.

Application

• Biomedical Research: Used as a reference standard and active probe in studies of gonadotropin-releasing hormone (GnRH) receptor signaling pathways and mechanisms.
• Drug Discovery & Development: Serves as a key intermediate or lead compound in the design and synthesis of novel peptide-based therapeutics targeting hormone-dependent conditions.
• Endocrinology Studies: Employed in in vitro and in vivo models to investigate pituitary function, hormone regulation, and reproductive biology.
• Oncology Research: Investigated for its potential role and effects in hormone-sensitive cancers, such as prostate and breast cancer research models.
• Peptide Chemistry & Analysis: Acts as a high-purity substrate for method development in analytical techniques like HPLC and mass spectrometry.
• Bioconjugation & Labeling: Can be used as a base structure for creating labeled (e.g., fluorescent, radioactive) peptides for diagnostic or tracking applications.

Basic Information

Product Name	Lhrh, Ac-Dehydro-Pro(1)-4-Cl-Phe(2)-Trp(3,6)- CAS NO 80152-22-3
CAS No.	80152-22-3
Molecular Formula	C64H83ClN16O12
Molecular Weight	1287.9 g/mol (approx.)
Synonyms	Ac-δ-Pro1,4-Cl-D-Phe2,D-Trp3,6-LHRH; [Ac-δ-Pro1,4-Cl-D-Phe2,D-Trp3,6]-LHRH; GnRH Antagonist Analog; Luteinizing Hormone-Releasing Hormone Antagonist (modified); 80152-22-3; Ac-dehydro-Pro-4-chloro-D-Phe-D-Trp-LHRH; Modified LHRH Peptide
EINECS	Contact for details

Quality Control

Our peptide products are manufactured and controlled under strict quality management systems. Each batch of Lhrh, Ac-Dehydro-Pro(1)-4-Cl-Phe(2)-Trp(3,6)- undergoes comprehensive analytical testing, including HPLC for purity determination, mass spectrometry (MS) for identity confirmation, and amino acid analysis (AAA). Certificates of Analysis (COA) detailing purity, peptide content, and solvent residues are provided and available upon request to support your research and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dedicated freezer. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture absorption. For long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Peptide Content	≥ 80.0% (by weight)
Single Impurity (HPLC)	≤ 1.0%
Amino Acid Analysis	Within ± 10% of theoretical
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC/IC)	≤ 10.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.