Description

L-3-Chlorophenylalanine is a halogenated derivative of the essential amino acid phenylalanine, where a chlorine atom is substituted at the meta position of the phenyl ring. This structural modification makes it a valuable chiral building block and intermediate in advanced organic synthesis, particularly for creating novel pharmaceutical compounds and bioactive molecules. It is essential for research and development in the pharmaceutical, agrochemical, and fine chemical industries, where precise molecular architecture is required.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and production of active pharmaceutical ingredients (APIs), especially for central nervous system (CNS) drugs and enzyme inhibitors.
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis to incorporate a chlorinated aromatic moiety, modifying peptide stability, lipophilicity, and receptor binding affinity.
• Agrochemical Research: Serves as a precursor in developing novel herbicides, fungicides, and plant growth regulators with targeted activity.
• Biochemical Research: Employed in enzymatic studies and as a substrate analog to investigate metabolic pathways involving aromatic amino acids.
• Fine Chemical Synthesis: A versatile intermediate for synthesizing complex organic molecules, including liquid crystals, dyes, and specialty polymers.
• Asymmetric Catalysis: Used as a ligand or a starting material for chiral auxiliaries and catalysts in stereoselective synthesis.

Basic Information

Product Name	L-3-Chlorophenylalanine
CAS No.	80126-51-8
Molecular Formula	C9H10ClNO2
Molecular Weight	199.63 g/mol
Synonyms	(S)-2-Amino-3-(3-chlorophenyl)propanoic acid; L-3-Chlorophenylalanine; (S)-3-Chloro-DL-phenylalanine; 3-Chloro-L-phenylalanine; L-m-Chlorophenylalanine; H-3-Cl-Phe-OH; 80126-51-8; (S)-α-Amino-3-chlorobenzenepropanoic acid
EINECS	Contact for details

Quality Control

Our L-3-Chlorophenylalanine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification, to ensure it meets stringent specifications for research and industrial use. Certificates of Analysis (COA) detailing purity, enantiomeric excess, and impurity profiles are provided with every shipment to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This compound is moisture-sensitive; keep the container tightly sealed in a dry environment.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms
Assay (HPLC)	≥98.0%
Enantiomeric Excess (Chiral HPLC)	≥99.0%
Loss on Drying	≤0.5%
Residue on Ignition (Sulfated Ash)	≤0.1%
Heavy Metals (as Pb)	≤10 ppm
Related Substances (HPLC)	Total impurities ≤1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.