Description

2-Chloro-D-Phenylalanine is a non-natural, chiral amino acid derivative of significant interest in advanced pharmaceutical and biochemical research. This compound serves as a critical chiral building block and a key intermediate in the synthesis of more complex bioactive molecules. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel therapeutics, peptide-based drugs, and specialized biochemical probes.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new active pharmaceutical ingredients (APIs), particularly for metabolic and neurological disorders.
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis to incorporate a chlorinated phenylalanine residue, modifying peptide stability, lipophilicity, and receptor binding affinity.
• Biochemical Research: Employed as a substrate or inhibitor in enzymatic studies to investigate amino acid metabolism and transport mechanisms.
• Proteomics & Labeling: Acts as a specialty amino acid for metabolic labeling or as a building block for creating custom amino acid analogs in protein engineering.
• Reference Standard: Serves as a high-purity chromatographic reference standard for quality control and analytical method development in pharmaceutical labs.

Basic Information

Product Name	2-Chloro-D-Phenylalanine
CAS No.	80126-50-7
Molecular Formula	C9H10ClNO2
Molecular Weight	199.63 g/mol
Synonyms	(R)-2-Amino-3-(2-chlorophenyl)propanoic acid; D-2-Chlorophenylalanine; (R)-2-Chloro-DL-phenylalanine; D-(2-Chlorophenyl)alanine; 2-Cl-D-Phe; 80126-50-7; D-2-Chloro-phenylalanine
EINECS	Contact for details

Quality Control

Our 2-Chloro-D-Phenylalanine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for research and pharmaceutical applications. A Certificate of Analysis (COA) detailing purity, specific rotation, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% (D-isomer)
Specific Rotation	Contact for details
Loss on Drying	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.