Description

2-Propargyloxy-5-Chloropyrimidine is a versatile halogenated pyrimidine derivative featuring a reactive propargyl ether moiety. This compound is a crucial high-purity building block in advanced organic synthesis, particularly valued for its dual functionality which enables selective chemical modifications. It is primarily sought after by pharmaceutical R&D and agrochemical laboratories for the development of novel active ingredients and complex molecular architectures.

Application

• Pharmaceutical Intermediate: Key synthon in the research and development of novel drug candidates, especially in kinase inhibitor and antiviral agent synthesis.
• Agrochemical Synthesis: Building block for creating advanced herbicides, fungicides, and plant growth regulators with specific modes of action.
• Material Science Research: Used in the development of specialty polymers and functional materials via click chemistry reactions involving the alkyne group.
• Chemical Biology Probes: Serves as a precursor for labeling reagents and molecular probes used in bio-conjugation and target identification studies.
• Academic & Industrial R&D: Fundamental research reagent in heterocyclic and medicinal chemistry for constructing complex pyrimidine-based libraries.

Basic Information

Product Name	2-Propargyloxy-5-Chloropyrimidine
CAS No.	80016-43-9
Molecular Formula	C7H5ClN2O
Molecular Weight	168.58 g/mol
Synonyms	5-Chloro-2-(prop-2-yn-1-yloxy)pyrimidine; 5-Chloro-2-propargyloxypyrimidine; 2-(Prop-2-ynyloxy)-5-chloropyrimidine; 5-Chloro-2-(2-propynyloxy)pyrimidine; Propargyl 5-chloropyrimidin-2-yl ether; 5-Chloro-2-(propagyloxy)pyrimidine; 2-Propargyloxy-5-chloropyrimidine; 80016-43-9
EINECS	Contact for details

Quality Control

Our 2-Propargyloxy-5-Chloropyrimidine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. We adhere to relevant industry standards for fine chemical intermediates, and custom purity grades (e.g., >97%, >98%, >99%) are available to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its sensitivity to oxidation, it is recommended to store under an inert atmosphere (e.g., nitrogen or argon) for long-term preservation. Keep away from heat, sparks, and open flames.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.