Description

Essaven CAS NO 8067-31-0 is a standardized botanical extract derived from horse chestnut (*Aesculus hippocastanum*), primarily valued for its high content of active triterpene saponins, notably aescin. This compound is crucial for its potent venotonic and anti-inflammatory properties, making it a key ingredient in the development of pharmaceutical and nutraceutical formulations. It is essential for manufacturers in the pharmaceutical, cosmeceutical, and dietary supplement industries seeking reliable, high-purity active ingredients for vascular health and topical applications.

Application

• Pharmaceutical Formulations: Primary active ingredient in oral and topical medications for chronic venous insufficiency (CVI), hemorrhoids, and post-operative edema.
• Dietary Supplements: Used in capsule, tablet, and liquid supplement formats to support circulatory health and reduce leg swelling and heaviness.
• Cosmeceutical Products: Incorporated into creams, gels, and serums for its anti-inflammatory and capillary-strengthening effects, targeting under-eye circles, redness, and varicose veins.
• Topical Preparations: Key component in ointments and gels for the relief of bruises, sprains, and sports-related injuries due to its anti-edema properties.
• Veterinary Medicine: Used in formulations for treating swelling and inflammation in animals.
• Research & Development: Serves as a reference standard and active material in pharmacological studies related to vascular permeability and inflammation.

Basic Information

Product Name	Essaven
CAS No.	8067-31-0
Molecular Formula	Mixture (Standardized Extract)
Molecular Weight	N/A (Mixture)
Synonyms	Aescin; Escin; β-Aescin; Horse Chestnut Extract; Aesculus hippocastanum Extract; Venostasin; Reparil; Venoplant; Venocuran; Venaforce
EINECS	Contact for details

Quality Control

Our Essaven is produced under strict quality management systems to ensure batch-to-batch consistency and efficacy. The extract is standardized to a defined content of aescin (typically 16-20% or as specified), with rigorous testing for identity, purity, and residual solvents. A comprehensive Certificate of Analysis (COA) is provided with each batch, detailing specifications for assay, heavy metals, microbial limits, and other critical parameters in compliance with relevant pharmacopeial guidelines (e.g., USP, Ph. Eur.).

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); ensure the container is kept tightly sealed in a low-humidity environment to prevent absorption of moisture and maintain stability.

Specification

Item	Specification
Appearance	Fine, yellowish-brown to brown powder
Identification (HPLC/TLC)	Complies
Assay (Aescin Content)	Min. 16.0% (HPLC)
Loss on Drying	≤ 5.0%
Residue on Ignition	≤ 1.0%
Heavy Metals (as Pb)	≤ 20 ppm
Total Aerobic Microbial Count	≤ 1000 CFU/g
Total Combined Yeasts & Molds	≤ 100 CFU/g
Solvent Residues	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.