Description

Cascara Sagrada is a botanical extract derived from the dried bark of *Rhamnus purshiana*, standardized by its CAS number 8007-06-5. This natural product is valued for its primary bioactive components, anthraquinone glycosides, which serve as key active principles. It is a critical ingredient for manufacturers in the pharmaceutical and nutraceutical industries seeking reliable, high-quality botanical raw materials for formulated products.

Application

• Pharmaceutical Formulations: Primarily used as an active pharmaceutical ingredient (API) in over-the-counter (OTC) laxative and digestive aid products.
• Dietary Supplements & Nutraceuticals: Incorporated into capsules, tablets, and herbal blends aimed at supporting digestive health and regularity.
• Traditional Herbal Medicine: Serves as a base material for the preparation of traditional tinctures, fluid extracts, and powdered herbs.
• Veterinary Pharmaceuticals: Used in animal health products for digestive regulation in livestock and companion animals.
• Research & Development: Supplied to laboratories for pharmacological studies, standardization methods, and analytical reference material.

Basic Information

Product Name	Cascara Sagrada
CAS No.	8007-06-5
Molecular Formula	Not Applicable (Complex Botanical Extract)
Molecular Weight	Not Applicable
Synonyms	Cascara; Sacred Bark; Rhamnus Purshiana Bark Extract; Chittem Bark; Persian Bark; Bearberry; Bitter Bark; Purshiana Bark; California Buckthorn
EINECS	Contact for details

Quality Control

Our Cascara Sagrada is produced and tested to meet stringent quality standards suitable for pharmaceutical and nutraceutical applications. Quality assurance includes identity confirmation, assay of total anthracene derivatives, and limits for key impurities. We provide full traceability and support compliance with relevant pharmacopoeial standards (e.g., USP, Ph. Eur.). Certificates of Analysis (COA) documenting purity, potency, and safety are available for every batch upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent absorption of atmospheric moisture, which can affect stability and potency.

Specification

Item	Specification
Description	Fine brown powder with characteristic odor
Identification (TLC/HPLC)	Complies with standard
Assay (Total Anthracene Glycosides)	Min. 8.0% (calculated as cascaroside A)
Loss on Drying	≤ 12.0 %
Total Ash	≤ 6.0 %
Acid-Insoluble Ash	≤ 3.0 %
Heavy Metals	≤ 20 ppm
Microbial Limits	Complies with Ph. Eur./USP
Residual Solvents	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.