Description

2-[2,2,2-Trifluoro-1-Hydroxy-1-(Trifluoromethyl)Ethyl]Phenol is a high-value fluorinated phenolic compound that serves as a critical advanced intermediate in modern synthetic chemistry. Its unique structure, featuring a geminal bis(trifluoromethyl) carbinol group, provides exceptional utility for introducing steric bulk and lipophilicity into target molecules. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries seeking to enhance the metabolic stability and bioavailability of new active ingredients.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in the development of anti-inflammatory, antiviral, and central nervous system (CNS) drugs.
• Agrochemical Synthesis: Used in creating advanced herbicides, fungicides, and insecticides where the fluorinated moiety improves environmental persistence and target specificity.
• Liquid Crystal Materials: Serves as a precursor for fluorinated mesogens, which are critical components in high-performance display technologies.
• Polymer Modification: Employed to introduce fluorine-containing side chains into polymers, enhancing their chemical resistance, thermal stability, and surface properties.
• Organic Synthesis Reagent: Acts as a versatile reagent for constructing complex, fluorinated organic architectures in academic and industrial research settings.
• Advanced Material Development: Utilized in the R&D of specialty coatings, electronic chemicals, and other performance materials requiring specific fluorine-based functionalities.

Basic Information

Product Name	2-[2,2,2-Trifluoro-1-Hydroxy-1-(Trifluoromethyl)Ethyl]Phenol
CAS No.	836-78-2
Molecular Formula	C9H5F6O2
Molecular Weight	250.13 g/mol
Synonyms	2-(1-Hydroxy-3,3,3-trifluoro-2-(trifluoromethyl)propyl)phenol; 2-(3,3,3-Trifluoro-2-hydroxy-2-(trifluoromethyl)propyl)phenol; 1,1,1,3,3,3-Hexafluoro-2-(2-hydroxyphenyl)propan-2-ol; Hexafluorobisphenol AF Intermediate; Bisphenol AF Derivative; α-(2-Hydroxyphenyl)-α-(trifluoromethyl)-3,3,3-trifluoro-1-propanol; Phenol, 2-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-
EINECS	Contact for details

Quality Control

Our production of 2-[2,2,2-Trifluoro-1-Hydroxy-1-(Trifluoromethyl)Ethyl]Phenol adheres to stringent quality management systems to ensure batch-to-batch consistency and high purity. The material is subjected to rigorous analytical testing, including HPLC, GC, NMR, and IR spectroscopy, to confirm identity and quantify impurities. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and specific impurity profiles is provided with each shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from heat, open flames, and incompatible materials. Due to its light-sensitive nature, containers should be amber-colored or stored in light-resistant secondary packaging.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.