Description

2,4-Diamino-5-(4-Fluorobenzyl)Pyrimidine is a high-purity, fluorinated pyrimidine derivative that serves as a critical building block in advanced organic synthesis. This compound is valued for its role as a key intermediate in the development of active pharmaceutical ingredients (APIs), particularly in the synthesis of dihydrofolate reductase (DHFR) inhibitors. It is essential for research and production teams in the pharmaceutical, agrochemical, and fine chemical industries seeking reliable, high-quality intermediates for complex molecular construction.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of dihydrofolate reductase (DHFR) inhibitor drugs, including certain classes of antibiotics and antimalarials.
• Agrochemical Synthesis: Used in the research and development of novel herbicides and fungicides, leveraging the pyrimidine core for biological activity.
• Fine Chemical Production: Serves as a versatile building block for creating complex fluorinated organic molecules in custom synthesis projects.
• Biochemical Research: Employed in academic and industrial laboratories as a standard or reagent for studying enzyme inhibition and structure-activity relationships (SAR).
• Material Science: Investigated for potential use in the development of specialty polymers and advanced organic electronic materials due to its aromatic and heterocyclic structure.

Basic Information

Product Name	2,4-Diamino-5-(4-Fluorobenzyl)Pyrimidine
CAS No.	836-06-6
Molecular Formula	C11H11FN4
Molecular Weight	218.23 g/mol
Synonyms	5-(4-Fluorobenzyl)-2,4-pyrimidinediamine; 2,4-Diamino-5-(4-fluorobenzyl)pyrimidine; 5-(4-Fluorobenzyl)pyrimidine-2,4-diamine; NSC 329680; 4-Fluorobenzylpyrimidine derivative; 2,4-Pyrimidinediamine, 5-[(4-fluorophenyl)methyl]-; 5-(p-Fluorobenzyl)-2,4-diaminopyrimidine
EINECS	Contact for details

Quality Control

Our 2,4-Diamino-5-(4-Fluorobenzyl)Pyrimidine is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via FT-IR and NMR spectroscopy, to ensure it meets the high standards required for pharmaceutical and research applications. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.