Description

p-Trifluoromethoxy Phenol is a versatile fluorinated aromatic compound characterized by a phenol group substituted with a trifluoromethoxy moiety at the para position. This unique structure imparts valuable properties such as enhanced lipophilicity and metabolic stability, making it a critical intermediate for advanced chemical synthesis. It is primarily sought after by R&D and production teams in the pharmaceutical, agrochemical, and specialty chemical industries for constructing complex molecules.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for compounds requiring fluorinated aromatic systems to modulate bioavailability and potency.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides, where the trifluoromethoxy group contributes to improved biological activity and environmental persistence.
• Liquid Crystal Materials: Serves as a precursor in the manufacture of fluorinated liquid crystals for high-performance displays (LCDs).
• Polymer & Material Science: Incorporated as a monomer or modifier to create specialty polymers with enhanced chemical resistance, thermal stability, and unique surface properties.
• Organic Synthesis Reagent: Employed in cross-coupling reactions and as a protecting group or directing group in complex organic transformations within research laboratories.

Basic Information

Product Name	p-Trifluoromethoxy Phenol
CAS No.	828-27-3
Molecular Formula	C7H5F3O2
Molecular Weight	178.11 g/mol
Synonyms	4-(Trifluoromethoxy)phenol; 1-Hydroxy-4-(trifluoromethoxy)benzene; Phenol, 4-(trifluoromethoxy)-; 4-Hydroxy-α,α,α-trifluoroanisole; p-Hydroxy-α,α,α-trifluoroanisole; 4-Trifluoromethoxyphenol; F3CO-Ph-OH
EINECS	212-595-8

Quality Control

Our p-Trifluoromethoxy Phenol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from strong oxidizing agents and bases.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	40 - 44 °C
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.