Description

8-Chlorotheophylline is a key pharmaceutical intermediate and a versatile organic building block. This compound is primarily valued for its role in synthesizing diphenhydramine salts, such as dimenhydrinate, which are critical in antiemetic and antihistamine formulations. It is essential for manufacturers in the pharmaceutical, fine chemical, and research sectors requiring high-purity intermediates for API development and specialized synthesis.

Application

• Pharmaceutical Intermediate: Primary use in the synthesis of dimenhydrinate and other diphenhydramine-based antiemetic and antihistamine APIs.
• Fine Chemical Synthesis: Serves as a versatile building block for creating novel xanthine derivatives and other complex organic molecules in research and development.
• Active Pharmaceutical Ingredient (API) Manufacturing: Used in the production of finished dosage forms for motion sickness and allergy medications.
• Biochemical Research: Employed as a reference standard and as a tool compound in pharmacological studies targeting adenosine receptors.
• Chemical Reference Standard: Supplied to analytical laboratories and quality control departments for method development and verification.

Basic Information

Product Name	8-Chlorotheophylline
CAS No.	85-18-7
Molecular Formula	C7H7ClN4O2
Molecular Weight	214.61 g/mol
Synonyms	8-Chloro-1,3-dimethyl-3,7-dihydro-1H-purine-2,6-dione; 8-Chloro-1,3-dimethylxanthine; 8-Chlorotheophylline; 1,3-Dimethyl-8-chloroxanthine; NSC 403697; Theophylline, 8-chloro-; 8-Chloro-1,3-dimethyl-2,6-dioxopurine
EINECS	201-590-9

Quality Control

Our 8-Chlorotheophylline is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation by IR spectroscopy, to ensure it meets exacting standards suitable for pharmaceutical applications. A detailed Certificate of Analysis (COA) is provided with every shipment to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Assay (HPLC)	≥ 98.5%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.