Description

5-Bromo-2-(trifluoromethyl)pyrimidine is a high-value halogenated pyrimidine building block essential for advanced organic synthesis. This compound matters for its unique trifluoromethyl and bromo substituents, which are critical for modulating the physicochemical and biological properties of target molecules. It is primarily needed by research chemists and process development scientists in the pharmaceutical and agrochemical industries for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in kinase inhibitor and antiviral drug discovery programs.
• Agrochemical Synthesis: Used in the research and production of novel herbicides, fungicides, and insecticides, where the CF3 group enhances lipophilicity and metabolic stability.
• Material Science Precursor: Serves as a building block for functionalized polymers, liquid crystals, and organic electronic materials.
• Cross-Coupling Reactions: The bromine atom makes it an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Stille, Negishi) to form complex biaryl structures.
• Nucleophilic Substitution: The pyrimidine core allows for further functionalization via nucleophilic aromatic substitution, enabling rapid diversification of chemical libraries.
• Fluorine Chemistry Research: An important reagent for studying the effects of fluorine substitution in medicinal and agricultural chemistry.

Basic Information

Product Name	5-Bromo-2-(trifluoromethyl)pyrimidine
CAS No.	799557-86-1
Molecular Formula	C5H2BrF3N2
Molecular Weight	226.98 g/mol
Synonyms	5-Bromo-2-(trifluoromethyl)pyrimidine; 2-(Trifluoromethyl)-5-bromopyrimidine; 5-Bromo-2-trifluoromethylpyrimidine; Pyrimidine, 5-bromo-2-(trifluoromethyl)-; 799557-86-1; 5-Bromo-2-(trifluoromethyl)pyrimidine CAS 799557-86-1
EINECS	Contact for details

Quality Control

Our 5-Bromo-2-(trifluoromethyl)pyrimidine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high purity and batch-to-batch consistency. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area away from incompatible materials such as strong acids and bases. Recommended storage temperature: 2-8°C for long-term stability. The compound is light-sensitive and should be stored away from light.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.