Description

5-Pyrimidinecarbonitrile,1-[(2R)-2,3-Dihydroxypropyl]-1,2,3,4-Tetrahydro-3-Methyl-2,4-Dioxo-(9Ci) is a high-purity, advanced pharmaceutical intermediate characterized by its specific stereochemistry and functionalized pyrimidine core. This compound matters as a critical building block in the synthesis of complex, biologically active molecules, offering researchers and manufacturers a reliable and well-defined starting material. It is primarily needed by pharmaceutical R&D teams and fine chemical producers engaged in developing novel therapeutics, particularly in antiviral and oncology research.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new active pharmaceutical ingredients (APIs).
• Antiviral Drug Research: Serves as a crucial precursor in the synthesis of nucleoside/nucleotide analogs and other antiviral candidates.
• Oncology Therapeutics: Used in the construction of targeted kinase inhibitors and other small-molecule cancer treatments.
• Biochemical Research: Employed as a substrate or inhibitor in enzymatic studies and proteomics research.
• Process Chemistry: Utilized for scale-up and optimization in the commercial manufacturing of specialty fine chemicals.
• Custom Synthesis: A starting point for contract research organizations (CROs) and CDMOs performing bespoke synthesis for clients.

Basic Information

Product Name	5-Pyrimidinecarbonitrile,1-[(2R)-2,3-Dihydroxypropyl]-1,2,3,4-Tetrahydro-3-Methyl-2,4-Dioxo-(9Ci)
CAS No.	799261-92-0
Molecular Formula	C9H11N3O4
Molecular Weight	225.20 g/mol
Synonyms	1-[(2R)-2,3-Dihydroxypropyl]-3-methyl-2,4-dioxo-1,2,3,4-tetrahydro-5-pyrimidinecarbonitrile; (R)-1-(2,3-Dihydroxypropyl)-3-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidine-5-carbonitrile; 5-Cyano-1-[(2R)-2,3-dihydroxypropyl]-3-methylpyrimidine-2,4(1H,3H)-dione; A Chiral Dihydroxypropyl Pyrimidinedione Derivative; Contact for additional synonyms.
EINECS	Contact for details

Quality Control

Our 5-Pyrimidinecarbonitrile,1-[(2R)-2,3-Dihydroxypropyl]-1,2,3,4-Tetrahydro-3-Methyl-2,4-Dioxo-(9Ci) is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure compliance with exacting research and pharmaceutical intermediate standards. Comprehensive Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.