Description

(E)-(4R)-4,5-Isopropylidene-Dioxy-1-(2-Hydroxy-5-Fluorophenyl)Propenone is a high-purity, chiral organic intermediate characterized by its specific stereochemistry and functional groups. This compound matters for its role as a critical building block in the synthesis of complex, biologically active molecules, offering precise control over the final product's stereochemical and pharmacological properties. It is primarily needed by pharmaceutical R&D and fine chemical synthesis teams developing advanced active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring fluorinated and protected diol motifs.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of novel Active Pharmaceutical Ingredients (APIs).
• Organic Synthesis Building Block: Used in complex multi-step syntheses, including asymmetric catalysis and cross-coupling reactions.
• Medicinal Chemistry Research: Serves as a precursor for creating compound libraries in drug discovery programs targeting various diseases.
• Fluorinated Compound Synthesis: Exploited for introducing the 5-fluoro substituent into target molecules to modulate their bioavailability and metabolic stability.
• Acetal-Protected Diol Chemistry: The isopropylidene dioxy group serves as a protective strategy for vicinal diols during synthetic sequences.
• Chemical Biology Probes: Can be utilized in the development of molecular probes for studying enzyme mechanisms or biological pathways.

Basic Information

Product Name	(E)-(4R)-4,5-Isopropylidene-Dioxy-1-(2-Hydroxy-5-Fluorophenyl)Propenone
CAS No.	797054-17-2
Molecular Formula	C13H13FO4
Molecular Weight	252.24 g/mol
Synonyms	(4R)-4,5-O-Isopropylidene-1-(2-hydroxy-5-fluorophenyl)-1-propenone; (E)-1-(2-Hydroxy-5-fluorophenyl)-3-[(4R)-2,2-dimethyl-1,3-dioxolan-4-yl]-2-propen-1-one; (4R)-4,5-Isopropylidenedioxy-1-(2-hydroxy-5-fluorophenyl)propenone; (E)-4,5-Isopropylidene-Dioxy-1-(2-Hydroxy-5-Fluorophenyl)Propenone; 797054-17-2; (R)-4,5-O-Isopropylidene-1-(2-hydroxy-5-fluorophenyl)propenone; Chiral fluorinated propenone derivative; Acetophenone, 2',5-difluoro-4,5-O-(1-methylethylidene)-, (4R)-
EINECS	Contact for details

Quality Control

Our (E)-(4R)-4,5-Isopropylidene-Dioxy-1-(2-Hydroxy-5-Fluorophenyl)Propenone is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including chiral purity assessment by HPLC, to ensure it meets the high standards required for pharmaceutical R&D. A detailed Certificate of Analysis (COA) confirming identity, purity, and chiral excess is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The container should be kept in a well-ventilated area and protected from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Related Substances (HPLC)	Total impurities ≤ 2.0%
Any single unknown impurity	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.