Description

(E)-(4R)-4,5-Isopropylidene-Dioxy-1-(2-Hydroxy-5-Fluorophenyl)Propenone is a high-purity chiral building block and advanced pharmaceutical intermediate. This compound is valued for its defined stereochemistry and functional groups, which are critical for synthesizing complex bioactive molecules. It is primarily sought by research institutions and pharmaceutical manufacturers engaged in the development of novel therapeutic agents, particularly in areas requiring fluorinated and protected diol motifs.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new active pharmaceutical ingredients (APIs), especially for central nervous system (CNS) and anti-inflammatory targets.
• Organic Synthesis Building Block: Used in asymmetric synthesis and cross-coupling reactions to construct complex molecular architectures due to its reactive propenone and protected diol functionalities.
• Medicinal Chemistry Research: Serves as a core scaffold for structure-activity relationship (SAR) studies and library synthesis in drug discovery programs.
• Fluorinated Compound Synthesis: The 5-fluoro substituent makes it a valuable precursor for introducing fluorine atoms into target molecules to modulate pharmacokinetics and metabolic stability.
• Process Chemistry Development: Employed in scaling up synthetic routes from laboratory to pilot plant scale for clinical trial material production.
• Reference Standard: Used as an analytical standard for quality control and method validation in pharmaceutical manufacturing.

Basic Information

Product Name	(E)-(4R)-4,5-Isopropylidene-Dioxy-1-(2-Hydroxy-5-Fluorophenyl)Propenone
CAS No.	797054-16-1
Molecular Formula	C13H13FO4
Molecular Weight	252.24 g/mol
Synonyms	(E)-1-(2-Hydroxy-5-fluorophenyl)-3-[(4R)-2,2-dimethyl-1,3-dioxolan-4-yl]prop-2-en-1-one; (4R)-4,5-O-Isopropylidene-1-(2-hydroxy-5-fluorophenyl)propenone; (E)-4,5-Isopropylidenedioxy-1-(2-hydroxy-5-fluorophenyl)propenone; (R)-4,5-O-Isopropylidene-1-(2-hydroxy-5-fluorophenyl)propenone; 797054-16-1; (E)-Chalcone derivative, fluorinated; (4R)-Protected diol fluorophenyl propenone
EINECS	Contact for details

Quality Control

Our (E)-(4R)-4,5-Isopropylidene-Dioxy-1-(2-Hydroxy-5-Fluorophenyl)Propenone is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification, to ensure it meets the high standards required for pharmaceutical R&D. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The compound is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.