Description

n-(2-Methyl-4-Nitrophenyl)-4-(3-Pyridinyl)-2-Pyrimidinamine CAS NO 796738-71-1 is a high-purity, advanced pharmaceutical intermediate characterized by its complex heterocyclic structure. This compound is of significant commercial importance for its role in the research and development of novel therapeutic agents, particularly kinase inhibitors. It is primarily sought by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in the synthesis of targeted drug candidates.

Application

This specialized intermediate serves as a critical building block in several advanced chemical synthesis pathways. Its primary applications include:

• Pharmaceutical Research & Development: Key precursor in the synthesis of novel kinase inhibitor candidates for oncology and other therapeutic areas.
• Active Pharmaceutical Ingredient (API) Synthesis: Used in the multi-step manufacturing process of targeted small-molecule drugs.
• Biochemical Research: Serves as a reference standard and a tool compound for studying enzyme inhibition and cellular signaling pathways.
• Contract Manufacturing Organizations (CMOs): Employed in custom synthesis projects for client-specific drug development programs.
• Academic Research: Utilized in universities and research institutes for medicinal chemistry and drug discovery projects.

Basic Information

Product Name	n-(2-Methyl-4-Nitrophenyl)-4-(3-Pyridinyl)-2-Pyrimidinamine
CAS No.	796738-71-1
Molecular Formula	C16H13N5O2
Molecular Weight	307.31 g/mol
Synonyms	4-(3-Pyridinyl)-N-(2-methyl-4-nitrophenyl)-2-pyrimidinamine; 2-Pyrimidinamine, N-(2-methyl-4-nitrophenyl)-4-(3-pyridinyl)-; TAE684 Intermediate; NVP-TAE684 Intermediate; NVP TAE684; N-(2-Methyl-4-nitrophenyl)-4-(pyridin-3-yl)pyrimidin-2-amine; ALK Inhibitor Intermediate; UNII-7VMA15G5VJ
EINECS	Contact for details

Quality Control

Our production of n-(2-Methyl-4-Nitrophenyl)-4-(3-Pyridinyl)-2-Pyrimidinamine adheres to stringent quality management protocols. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications and test results are provided and available upon request, supporting compliance in regulated research and development environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This product is light-sensitive (store away from light). Keep the container tightly sealed in a dry environment. For long-term storage, consider storage under inert atmosphere.

Specification

Item	Specification
Appearance	Yellow to light brown powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.