Description

4-(Trifluoromethyl)-1,4,5,6-Tetrahydropyrimidin-2-Amine is a high-value, fluorinated heterocyclic building block of significant interest in advanced organic synthesis. Its core value lies in the unique reactivity and physicochemical properties imparted by the trifluoromethyl group and the tetrahydropyrimidine scaffold, making it a critical intermediate for developing novel active compounds. This product is essential for research and development chemists in the pharmaceutical and agrochemical industries, where it is used to create new molecules with enhanced metabolic stability, bioavailability, and binding affinity.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel drug candidates, particularly in medicinal chemistry programs targeting central nervous system (CNS) disorders, anti-infectives, and oncology.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the fluorine atoms contribute to improved lipophilicity and environmental stability.
• Chemical Biology & Proteomics: Serves as a versatile scaffold for designing chemical probes and inhibitors to study enzyme function and biological pathways.
• Material Science Research: Investigated as a monomer or precursor for specialty polymers and advanced materials with specific electronic or surface properties.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences sector.

Basic Information

Product Name	4-(Trifluoromethyl)-1,4,5,6-Tetrahydropyrimidin-2-Amine
CAS No.	794477-74-0
Molecular Formula	C5H8F3N3
Molecular Weight	167.13 g/mol
Synonyms	2-Amino-4-(trifluoromethyl)-1,4,5,6-tetrahydropyrimidine; 4-(Trifluoromethyl)-1,4,5,6-tetrahydropyrimidin-2-amine; 1,4,5,6-Tetrahydro-4-(trifluoromethyl)-2-pyrimidinamine; 2-Amino-4-(trifluoromethyl)-1,4,5,6-tetrahydropyrimidine; 4-Trifluoromethyl-1,4,5,6-tetrahydropyrimidin-2-ylamine
EINECS	Contact for details

Quality Control

Every batch of 4-(Trifluoromethyl)-1,4,5,6-Tetrahydropyrimidin-2-Amine is manufactured under strict quality management protocols. Our products undergo rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high purity and batch-to-batch consistency essential for sensitive R&D and scale-up processes. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials such as strong bases and fluorides.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.