Description

Pyrimidine, 5-Ethynyl-4-Methoxy-2-Methyl-6-(Trifluoromethyl)- (9Ci) is a high-value, multi-functional heterocyclic building block designed for advanced synthetic chemistry. Its core value lies in the strategic combination of an ethynyl group for click chemistry or cross-coupling reactions and a trifluoromethyl group, which is critical for modulating the lipophilicity, metabolic stability, and bioavailability of target molecules. This compound is essential for research and development scientists in the pharmaceutical and agrochemical industries who require sophisticated intermediates for drug discovery and the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of novel small-molecule drug candidates, particularly in oncology, antiviral, and central nervous system (CNS) therapeutic areas.
• Agrochemical Research: Used in the development of next-generation herbicides, fungicides, and insecticides, where the trifluoromethyl group enhances biological activity and environmental stability.
• Material Science Precursor: Serves as a specialized monomer or cross-linking agent in the development of advanced polymers and functional materials.
• Chemical Biology Probe Development: The ethynyl handle allows for bioorthogonal labeling (e.g., via CuAAC or SPAAC click chemistry) to study protein interactions or cellular pathways.
• Fluorine Chemistry Research: An important substrate for studying the introduction and effects of fluorine atoms in complex molecular architectures.
• Ligand and Catalyst Design: Can be incorporated into novel ligands for catalysis or used to create metal-organic frameworks (MOFs).

Basic Information

Product Name	Pyrimidine, 5-Ethynyl-4-Methoxy-2-Methyl-6-(Trifluoromethyl)- (9Ci)
CAS No.	792934-98-6
Molecular Formula	C9H7F3N2O
Molecular Weight	216.16 g/mol
Synonyms	5-Ethynyl-4-methoxy-2-methyl-6-(trifluoromethyl)pyrimidine; 2-Methyl-5-ethynyl-4-methoxy-6-(trifluoromethyl)pyrimidine; 6-(Trifluoromethyl)-5-ethynyl-4-methoxy-2-methylpyrimidine; CAS 792934-98-6; Pyrimidine derivative with ethynyl and trifluoromethyl groups; 5-Ethynyl-4-methoxy-2-methyl-6-trifluoromethylpyrimidine
EINECS	Contact for details

Quality Control

Our Pyrimidine, 5-Ethynyl-4-Methoxy-2-Methyl-6-(Trifluoromethyl)- (9Ci) is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity for research and development applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry standards, and specifications can be tailored to meet specific project requirements upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Keep away from incompatible materials such as strong alkalis and fluorides. For long-term storage, consider storing under an inert atmosphere to ensure optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.