Description

tert-Butyl 4-(4-Chloro-1H-Pyrazolo[3,4-D]Pyrimidin-1-Yl)Piperidine-1-Carboxylate is a high-purity, advanced pharmaceutical intermediate featuring a pyrazolopyrimidine core, a privileged scaffold in medicinal chemistry. This compound is critical for research and development programs targeting kinase inhibition, offering a versatile building block for the synthesis of novel therapeutic agents. It is primarily utilized by pharmaceutical R&D departments and fine chemical manufacturers engaged in developing treatments for oncology, inflammatory diseases, and other conditions modulated by kinase pathways.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the development of small-molecule kinase inhibitors for targeted cancer therapies.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization campaigns due to its pyrazolopyrimidine pharmacophore.
• API Synthesis: Serves as a critical building block in the multi-step synthesis of Active Pharmaceutical Ingredients (APIs) for clinical and commercial production.
• Biochemical Tool Compound: Employed in biochemical assays and high-throughput screening to study kinase function and identify new drug targets.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects under cGMP conditions.

Basic Information

Product Name	tert-Butyl 4-(4-Chloro-1H-Pyrazolo[3,4-D]Pyrimidin-1-Yl)Piperidine-1-Carboxylate
CAS No.	791852-35-2
Molecular Formula	C15H18ClN5O2
Molecular Weight	335.79 g/mol
Synonyms	1-Boc-4-(4-chloro-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidine; 4-(4-Chloro-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidine-1-carboxylic acid tert-butyl ester; tert-Butyl 4-(4-chloro-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidine-1-carboxylate; 1-(1-Boc-4-piperidyl)-4-chloro-pyrazolo[3,4-d]pyrimidine; 791852-35-2; 4-(4-Chloro-1H-pyrazolo[3,4-d]pyrimidin-1-yl)-1-piperidinecarboxylic acid 1,1-dimethylethyl ester
EINECS	Contact for details

Quality Control

Our tert-Butyl 4-(4-Chloro-1H-Pyrazolo[3,4-D]Pyrimidin-1-Yl)Piperidine-1-Carboxylate is manufactured under strict quality management systems. We provide material suitable for research and development use, with specifications tailored to meet the stringent requirements of pharmaceutical applications. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available for every batch. For advanced applications, we can discuss custom synthesis under controlled conditions to meet specific project needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The compound is light-sensitive and should be handled under appropriate conditions to maintain stability. For long-term storage, consider storage under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.