Description

4-Chloro-5,7-Difluoroquinazoline is a high-value, multi-functional heterocyclic building block essential for advanced organic synthesis. Its core value lies in its reactive chloro and fluoro substituents, which enable precise and efficient derivatization to create complex molecular architectures. This compound is critically needed by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of tyrosine kinase inhibitors (TKIs) and other targeted cancer therapies.
• Agrochemical Research: Used to construct novel quinazoline-based herbicides and fungicides with enhanced activity.
• Chemical Biology Probe Development: Serves as a scaffold for creating selective enzyme inhibitors and molecular probes for biological target validation.
• Material Science: A building block for advanced organic electronic materials and liquid crystals due to its rigid, planar structure.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs for the production of client-specific advanced intermediates under cGMP conditions.

Basic Information

Product Name	4-Chloro-5,7-Difluoroquinazoline
CAS No.	791602-75-0
Molecular Formula	C8H3ClF2N2
Molecular Weight	200.57 g/mol
Synonyms	5,7-Difluoro-4-chloroquinazoline; 4-Chloro-5,7-difluoroquinazoline; Quinazoline, 4-chloro-5,7-difluoro-; 791602-75-0; 4-Chloro-5,7-difluoro-quinazoline
EINECS	Contact for details

Quality Control

Our 4-Chloro-5,7-Difluoroquinazoline is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and KF titration for moisture content, to ensure it meets the stringent requirements of research and development. A detailed Certificate of Analysis (COA) is provided with every shipment, guaranteeing traceability and compliance with your specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); ensure containers are kept sealed to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.