Description

4-Quinazolineacetic Acid, 8-Fluoro-3,4-Dihydro-2-[4-(3-Methoxyphenyl)-1-Piperazinyl]-3-[2-Methoxy-5-(Trifluoromethyl)Phenyl]-, Methyl Ester is a sophisticated, high-purity pharmaceutical intermediate designed for advanced research and development. This compound matters as a key building block in the synthesis of novel therapeutic agents, offering researchers a reliable and well-characterized starting material. It is primarily needed by pharmaceutical R&D teams, biotechnology companies, and academic institutions focused on developing new drugs, particularly in areas like oncology and neurology.

Application

• Pharmaceutical Intermediate: Serves as a critical precursor in the multi-step synthesis of novel active pharmaceutical ingredients (APIs) for drug discovery programs.
• Medicinal Chemistry Research: Used as a core scaffold or building block for structure-activity relationship (SAR) studies to optimize drug candidate properties.
• Kinase Inhibitor Development: The quinazoline core structure makes it valuable for research into targeted therapies, such as kinase inhibitors for cancer treatment.
• Chemical Biology Probes: Employed in the development of chemical probes to study specific biological pathways and protein functions.
• Process Chemistry & Scale-Up: Used in route scouting and process optimization studies for the commercial-scale manufacturing of developmental drugs.
• Reference Standard: Acts as a high-purity analytical standard for quality control and method validation in pharmaceutical analysis.

Basic Information

Product Name	4-Quinazolineacetic Acid, 8-Fluoro-3,4-Dihydro-2-[4-(3-Methoxyphenyl)-1-Piperazinyl]-3-[2-Methoxy-5-(Trifluoromethyl)Phenyl]-, Methyl Ester
CAS No.	791117-40-3
Molecular Formula	C31H30F4N4O5
Molecular Weight	614.59 g/mol
Synonyms	Methyl 8-fluoro-3,4-dihydro-2-[4-(3-methoxyphenyl)-1-piperazinyl]-3-[2-methoxy-5-(trifluoromethyl)phenyl]-4-quinazolineacetate; 791117-40-3; 4-Quinazolineacetic acid, 8-fluoro-3,4-dihydro-2-[4-(3-methoxyphenyl)-1-piperazinyl]-3-[2-methoxy-5-(trifluoromethyl)phenyl]-, methyl ester; UNII-9Q2W2I6P4I; 9Q2W2I6P4I; SCHEMBL248422; BDBM50388823; AKOS025310626
EINECS	Contact for details

Quality Control

Our 4-Quinazolineacetic Acid, 8-Fluoro-3,4-Dihydro-2-[4-(3-Methoxyphenyl)-1-Piperazinyl]-3-[2-Methoxy-5-(Trifluoromethyl)Phenyl]-, Methyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment, supporting compliance with cGMP and ICH Q7 guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a cool, dry, and well-ventilated area. Keep the container sealed to protect this light-sensitive material from moisture and atmospheric contaminants.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Any single unknown impurity	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.