Description

4-(1,1-Difluoroethyl)- Benzenemethanamine is a specialized aromatic amine building block featuring a difluoroethyl substituent, offering unique electronic and steric properties for advanced synthesis. This compound is valued for its role as a key intermediate in the development of novel active pharmaceutical ingredients (APIs) and agrochemicals, where the fluorine atoms can enhance metabolic stability and bioavailability. It is primarily sought by research and development teams in the pharmaceutical, agrochemical, and advanced materials sectors for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of novel drug candidates, particularly in medicinal chemistry programs targeting central nervous system (CNS) disorders, oncology, and metabolic diseases.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the difluoroethyl group can contribute to improved efficacy and environmental profile.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands in asymmetric catalysis and organometallic chemistry.
• Material Science Research: Employed in the development of advanced polymers and functional materials with specific electronic or surface properties.
• Fluorine Chemistry Studies: A valuable substrate for academic and industrial research exploring the effects of fluorine substitution on chemical reactivity and physical properties.
• Custom Synthesis and Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for client-specific synthesis projects requiring high-purity fluorinated intermediates.

Basic Information

Product Name	4-(1,1-Difluoroethyl)- Benzenemethanamine
CAS No.	790601-53-5
Molecular Formula	C9H11F2N
Molecular Weight	171.19 g/mol
Synonyms	4-(1,1-Difluoroethyl)benzylamine; 1-[4-(Aminomethyl)phenyl]-1,1-difluoroethane; Benzenemethanamine, 4-(1,1-difluoroethyl)-; α-(4-(1,1-Difluoroethyl)phenyl)methylamine; (4-(1,1-Difluoroethyl)phenyl)methanamine; 4-(Difluoroethyl)benzylamine
EINECS	Contact for details

Quality Control

Every batch of 4-(1,1-Difluoroethyl)- Benzenemethanamine is produced and tested under a strict quality management system. Our products undergo rigorous quality testing, including advanced chromatographic and spectroscopic methods, to ensure compliance with industry standards and customer specifications. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request. We support cGMP (current Good Manufacturing Practice) standards for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Individual impurity ≤ 0.5% Total impurities ≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.