Description

2-Bromo-4-Methoxy-5-(Trifluoromethyl)Aniline is a high-value, multi-functional aromatic amine building block characterized by its bromine, methoxy, and trifluoromethyl substituents. This unique combination of functional groups makes it a critical intermediate for synthesizing advanced materials and active pharmaceutical ingredients (APIs) where electronic and steric properties must be precisely tuned. It is primarily utilized by research and development chemists, process scale-up engineers, and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries seeking to introduce specific motifs into complex molecular architectures.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders, oncology, and anti-inflammatory applications, where the trifluoromethyl group can enhance metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, leveraging the bromine atom for further functionalization and the CF3 group for improved lipophilicity and pest system uptake.
• Liquid Crystal & OLED Materials: Acts as a core building block for advanced electronic materials, including liquid crystals for displays and organic light-emitting diode (OLED) components, where its aniline core and substituents contribute to desired electronic and optical properties.
• Polymer Modification: Employed to introduce functional amine sites into polymer backbones or as a monomer for creating specialty polyamides and polyimides with enhanced thermal or chemical resistance.
• Dye & Pigment Manufacturing: Functions as an intermediate in the production of complex, high-performance dyes and pigments, where the bromine and methoxy groups allow for color tuning and improved fastness properties.
• Cross-Coupling Reactions: The bromine atom makes it an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig), enabling rapid diversification in medicinal chemistry and material science libraries.

Basic Information

Product Name	2-Bromo-4-Methoxy-5-(Trifluoromethyl)Aniline
CAS No.	789454-93-9
Molecular Formula	C8H7BrF3NO
Molecular Weight	270.05 g/mol
Synonyms	5-Amino-2-bromo-4-methoxybenzotrifluoride; 2-Bromo-4-methoxy-5-(trifluoromethyl)benzenamine; 2-Bromo-α,α,α-trifluoro-4-methoxy-m-toluidine; 1-Amino-2-bromo-4-methoxy-5-(trifluoromethyl)benzene; Benzenamine, 2-bromo-4-methoxy-5-(trifluoromethyl)-; 2-Bromo-4-methoxy-5-trifluoromethylaniline; 2-Br-4-MeO-5-CF3-Aniline
EINECS	Contact for details

Quality Control

Our 2-Bromo-4-Methoxy-5-(Trifluoromethyl)Aniline is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity, GC for residual solvents, and NMR/IR for structural confirmation, to ensure it meets the stringent requirements for advanced synthetic applications. Certificates of Analysis (COA) detailing all specifications and test results are provided and can be tailored to support regulatory filings (e.g., FDA DMF, CEP).

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under a dry atmosphere to prevent degradation. Keep away from strong alkalis and fluorides.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.