Description

4-(3-Chloro-4-Fluorophenylamino)-7-Methoxyquinazolin-6-Yl Acetate is a high-purity, advanced pharmaceutical intermediate belonging to the quinazoline class of compounds. This compound is a critical building block in the synthesis of targeted kinase inhibitors, offering significant value in modern drug discovery and development pipelines. It is primarily sought by pharmaceutical R&D laboratories, contract manufacturing organizations (CMOs), and fine chemical suppliers serving the global life sciences industry.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel tyrosine kinase inhibitors (TKIs) for oncology research.
• Active Pharmaceutical Ingredient (API) Development: Used in the research and process development of targeted cancer therapeutics.
• Biochemical Research: Serves as a reference standard and a tool compound for studying kinase signaling pathways in vitro.
• Preclinical Studies: Employed in the formulation and testing of drug candidates during early-stage development.
• Custom Synthesis: A starting material for the preparation of structurally related analogs for structure-activity relationship (SAR) studies.
• Process Chemistry: Used in scaling up and optimizing synthetic routes for the commercial production of related drug substances.

Basic Information

Product Name	4-(3-Chloro-4-Fluorophenylamino)-7-Methoxyquinazolin-6-Yl Acetate
CAS No.	788136-89-0
Molecular Formula	C17H13ClFN3O3
Molecular Weight	361.76 g/mol
Synonyms	6-Acetoxy-4-[(3-chloro-4-fluorophenyl)amino]-7-methoxyquinazoline; 4-[(3-Chloro-4-fluorophenyl)amino]-7-methoxy-6-quinazolinyl acetate; 7-Methoxy-6-acetoxy-4-(3-chloro-4-fluoroanilino)quinazoline; BIBX 1382 Diacetate Intermediate; Gefitinib Impurity; Gefitinib Related Compound; Quinazoline Acetate Derivative; EGFR Inhibitor Intermediate
EINECS	Contact for details

Quality Control

Our 4-(3-Chloro-4-Fluorophenylamino)-7-Methoxyquinazolin-6-Yl Acetate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliable supply for your most demanding R&D and scale-up projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.