Description

2,5-Dichloro-4-(Trifluoromethyl)Pyrimidine is a high-value halogenated pyrimidine building block essential for advanced organic synthesis. This compound matters for its role as a key intermediate in the development of active pharmaceutical ingredients (APIs) and agrochemicals, where its unique substitution pattern enables precise molecular modifications. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to introduce trifluoromethyl and chloro functionalities into complex molecules.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of novel drug candidates, particularly in kinase inhibitor and antiviral research.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides that require the trifluoromethylpyrimidine motif for enhanced activity and stability.
• Material Science Precursor: Serves as a monomer or functionalization agent in the creation of specialty polymers and advanced organic electronic materials.
• Chemical Research & Development: Employed in academic and industrial labs for method development, cross-coupling reactions, and nucleophilic substitution studies.
• Ligand and Catalyst Design: Utilized to construct complex heterocyclic ligands for catalysis and metal-organic frameworks (MOFs).
• Fluorinated Compound Library: A key reagent for generating diverse fluorinated compound libraries for high-throughput screening in drug discovery.

Basic Information

Product Name	2,5-Dichloro-4-(Trifluoromethyl)Pyrimidine
CAS No.	785777-98-2
Molecular Formula	C5HCl2F3N2
Molecular Weight	216.97 g/mol
Synonyms	4-(Trifluoromethyl)-2,5-dichloropyrimidine; 2,5-Dichloro-4-trifluoromethylpyrimidine; 2,5-Dichloro-4-(trifluoromethyl)pyrimidine; Pyrimidine, 2,5-dichloro-4-(trifluoromethyl)-; 785777-98-2; 2,5-Dichloro-4-(trifluoromethyl)pyrimidine; 4-(Trifluoromethyl)-2,5-dichloro-pyrimidine
EINECS	Contact for details

Quality Control

Our 2,5-Dichloro-4-(Trifluoromethyl)Pyrimidine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by NMR and IR spectroscopy, to ensure it meets the high standards required for synthetic applications. Certificates of Analysis (COA) with detailed specifications are provided for every shipment, ensuring traceability and batch-to-batch consistency for your critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for prolonged storage or after opening to maintain purity and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.