Description

2,5-Dibromo-4-(Trifluoromethyl)Pyrimidine is a high-value, multi-functional halogenated pyrimidine building block. This compound is critical for introducing both bromine and trifluoromethyl functional groups into complex molecular architectures, enabling precise modulation of electronic and steric properties. It is primarily utilized by research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for the synthesis of novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: A key synthon in the development of active pharmaceutical ingredients (APIs), particularly for kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and pesticides, leveraging the bioactivity of the pyrimidine core.
• Material Science: Serves as a precursor for organic electronic materials, such as ligands for OLEDs and charge-transport materials.
• Cross-Coupling Reactions: The bromine atoms are excellent handles for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Sonogashira) to create complex biaryl systems.
• Fluorine Chemistry Research: The stable trifluoromethyl group makes it a valuable compound for studying fluorine's effects on pharmacokinetics and material properties.
• Chemical Biology & Proteomics: Can be used to create molecular probes and tags for studying biological systems.

Basic Information

Product Name	2,5-Dibromo-4-(Trifluoromethyl)Pyrimidine
CAS No.	785777-91-5
Molecular Formula	C5HBr2F3N2
Molecular Weight	315.88 g/mol
Synonyms	4-(Trifluoromethyl)-2,5-dibromopyrimidine; 2,5-Dibromo-4-(trifluoromethyl)pyrimidine; 2,5-Dibromo-4-trifluoromethylpyrimidine; Pyrimidine, 2,5-dibromo-4-(trifluoromethyl)-; 4-Trifluoromethyl-2,5-dibromopyrimidine; 2,5-Dibromo-4-trifluoromethyl-pyrimidine
EINECS	Contact for details

Quality Control

Our 2,5-Dibromo-4-(Trifluoromethyl)Pyrimidine is produced under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment supports applications requiring high-purity building blocks for research and cGMP-compliant development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. This material is moisture-sensitive; keep the container tightly sealed under an inert atmosphere if necessary.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.