Description

5-Bromo-4-(Trifluoromethyl)Pyrimidin-2(1H)-One is a high-value, multi-functional heterocyclic building block characterized by its bromine and trifluoromethyl substituents, which are critical for modulating the physicochemical properties of target molecules. This compound matters because it serves as a versatile synthon in modern organic synthesis, enabling the rapid construction of complex molecular architectures with enhanced metabolic stability and bioavailability. It is primarily needed by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the discovery and development of new active ingredients.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel small-molecule drug candidates, particularly kinase inhibitors and antiviral agents.
• Agrochemical Research: Used to construct advanced pyrimidine-based herbicides, fungicides, and plant growth regulators.
• Material Science: Serves as a building block for specialty polymers, liquid crystals, and organic electronic materials.
• Chemical Biology: Employed in the development of molecular probes and labeled compounds for biochemical assays.
• Custom Synthesis: A starting material for contract research organizations (CROs) and CDMOs performing bespoke synthesis for client projects.

Basic Information

Product Name	5-Bromo-4-(Trifluoromethyl)Pyrimidin-2(1H)-One
CAS No.	785777-90-4
Molecular Formula	C5H2BrF3N2O
Molecular Weight	240.98 g/mol
Synonyms	5-Bromo-4-(trifluoromethyl)-1,2-dihydropyrimidin-2-one; 5-Bromo-4-(trifluoromethyl)-2-pyrimidinol; 5-Bromo-4-(trifluoromethyl)pyrimidin-2-ol; 2-Hydroxy-5-bromo-4-(trifluoromethyl)pyrimidine; 5-Bromo-4-trifluoromethyl-2(1H)-pyrimidinone; 785777-90-4; 5-Bromo-4-(trifluoromethyl)-2(1H)-pyrimidinone
EINECS	Contact for details

Quality Control

Our 5-Bromo-4-(Trifluoromethyl)Pyrimidin-2(1H)-One is produced under a strict quality management system. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high purity and batch-to-batch consistency suitable for research and development applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). The compound is moisture-sensitive; keep the container tightly sealed under an inert atmosphere for long-term storage.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.