Description

4-Bromo-6-(Trifluoromethyl)Pyrimidine is a high-value halogenated pyrimidine building block, distinguished by its bromine and trifluoromethyl substituents which impart unique reactivity and physicochemical properties. This compound is essential for facilitating structure-activity relationship (SAR) studies and accelerating the discovery of novel bioactive molecules. It is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of advanced intermediates and active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the development of kinase inhibitors, antiviral agents, and other small-molecule therapeutics.
• Agrochemical Research: Used in the synthesis of novel herbicides, fungicides, and insecticides, leveraging the bioactivity-enhancing trifluoromethyl group.
• Material Science Precursor: Serves as a building block for functionalized ligands, organic semiconductors, and advanced polymers.
• Cross-Coupling Reactions: The bromine atom makes it an excellent substrate for Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to create complex biaryl structures.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for target identification and validation in biological systems.

Basic Information

Product Name	4-Bromo-6-(Trifluoromethyl)Pyrimidine
CAS No.	785777-89-1
Molecular Formula	C5H2BrF3N2
Molecular Weight	226.98 g/mol
Synonyms	4-Bromo-6-(trifluoromethyl)pyrimidine; 6-(Trifluoromethyl)-4-bromopyrimidine; 4-Bromo-6-trifluoromethylpyrimidine; Pyrimidine, 4-bromo-6-(trifluoromethyl)-; 785777-89-1; 4-Br-6-CF3-Pyrimidine
EINECS	Contact for details

Quality Control

Our 4-Bromo-6-(Trifluoromethyl)Pyrimidine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for research and development. A detailed Certificate of Analysis (COA) is provided with every shipment, and custom purity grades are available to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong bases and reducing agents. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥97.0% (Standard Grade)
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.