Description

2-Bromo-4-(Trifluoromethyl)Pyrimidine is a high-value halogenated pyrimidine building block, essential for modern synthetic chemistry. Its core value lies in enabling the precise introduction of both bromine and trifluoromethyl functional groups into complex molecular architectures, facilitating rapid lead optimization and the development of novel active compounds. This intermediate is critically needed by R&D and process chemistry teams in the pharmaceutical, agrochemical, and advanced materials sectors seeking to enhance the potency, metabolic stability, and physicochemical properties of their target molecules.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of active pharmaceutical ingredients (APIs), particularly in kinase inhibitor and antiviral drug discovery programs.
• Agrochemical Research: Used in constructing novel herbicides, fungicides, and insecticides where the trifluoromethyl group imparts improved lipophilicity and biological activity.
• Ligand & Catalyst Development: Serves as a precursor for creating specialized ligands in transition metal catalysis and organocatalysis.
• Material Science: Incorporated into the design of advanced organic electronic materials, such as OLED emitters and charge-transport molecules.
• Chemical Biology: Employed as a probe or labeling reagent due to the reactivity of the bromine moiety for bioconjugation.
• Custom Synthesis & Contract Manufacturing: A fundamental building block for custom synthesis houses serving the life sciences industry.

Basic Information

Product Name	2-Bromo-4-(Trifluoromethyl)Pyrimidine
CAS No.	785777-87-9
Molecular Formula	C5H2BrF3N2
Molecular Weight	226.98 g/mol
Synonyms	2-Bromo-4-(trifluoromethyl)pyrimidine; 4-(Trifluoromethyl)-2-bromopyrimidine; 2-Bromo-4-trifluoromethylpyrimidine; Pyrimidine, 2-bromo-4-(trifluoromethyl)-; 2-Bromo-4-(trifluoromethyl)-1,3-diazine; BR-TFM-Pym
EINECS	Contact for details

Quality Control

Our 2-Bromo-4-(Trifluoromethyl)Pyrimidine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. We provide comprehensive analytical data, including HPLC, GC, NMR, and mass spectrometry characterization. A detailed Certificate of Analysis (COA) is supplied with each batch, confirming compliance with customer specifications and relevant industry standards for fine chemical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. The container should be kept tightly sealed in a dry environment to minimize exposure to moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.