Description

1-(3,4,5-Trifluorophenyl)Ethan-1-Amine is a high-purity fluorinated aromatic amine building block, essential for the synthesis of advanced pharmaceutical intermediates and agrochemicals. Its trifluoromethylphenyl core provides unique electronic and steric properties that are critical for modulating the bioactivity and metabolic stability of target molecules. This compound is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to introduce fluorine motifs into complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in CNS drugs, kinase inhibitors, and anti-infective agents.
• Agrochemical Synthesis: Used in the research and production of novel herbicides, fungicides, and insecticides where the trifluoromethyl group enhances lipophilicity and biological activity.
• Ligand and Catalyst Development: Serves as a precursor for chiral ligands and organocatalysts in asymmetric synthesis.
• Material Science: Employed in the synthesis of fluorinated polymers and advanced organic electronic materials.
• Chemical Research: A versatile building block for medicinal chemistry and discovery chemistry programs exploring structure-activity relationships (SAR).

Basic Information

Product Name	1-(3,4,5-Trifluorophenyl)Ethan-1-Amine
CAS No.	784129-18-6
Molecular Formula	C8H7F3N
Molecular Weight	174.14 g/mol
Synonyms	1-(3,4,5-Trifluorophenyl)ethanamine; α-Methyl-3,4,5-trifluorobenzeneethanamine; 1-(3,4,5-Trifluorophenyl)ethylamine; 3,4,5-Trifluoro-α-methylbenzeneethanamine; 2-(3,4,5-Trifluorophenyl)propan-2-amine (common misnomer); TFPA; 784129-18-6
EINECS	Contact for details

Quality Control

Our 1-(3,4,5-Trifluorophenyl)Ethan-1-Amine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and MS, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We support cGMP compliance for pharmaceutical applications and can tailor quality protocols to meet specific customer requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (nitrogen or argon) after opening to prevent moisture absorption and degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.