Description

Aloc-Arg(Pbf)-Oh CAS NO 783371-61-9 is a protected arginine derivative, specifically an amino acid building block where the α-amino group is protected by an allyloxycarbonyl (Aloc) group and the guanidino side chain is protected by a 2,2,4,6,7-pentamethyldihydrobenzofuran-5-sulfonyl (Pbf) group. This dual protection scheme is critical for enabling selective deprotection during complex peptide synthesis, particularly in solid-phase and solution-phase methodologies. It is an essential high-purity intermediate for research and development chemists in the pharmaceutical and biotechnology sectors, facilitating the production of peptides with challenging sequences or for use in conjugation strategies.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key building block for the controlled incorporation of arginine residues, especially in Fmoc/t-Bu chemistry.
• Solution-Phase Peptide Synthesis: Used in the fragment condensation approach for synthesizing longer or complex peptide chains.
• Pharmaceutical Intermediate: Serves as a critical raw material in the research and production of therapeutic peptides and peptidomimetics.
• Bioconjugation: The Aloc protecting group allows for orthogonal deprotection, enabling site-specific modification and labeling of peptides.
• Combinatorial Chemistry: Employed in libraries for drug discovery to explore structure-activity relationships of arginine-containing compounds.
• Academic & Industrial R&D: A standard reagent for developing novel synthetic methodologies and studying peptide structure and function.

Basic Information

Product Name	Aloc-Arg(Pbf)-Oh
CAS No.	783371-61-9
Molecular Formula	C₂₄H₃₇N₅O₇S
Molecular Weight	539.65 g/mol
Synonyms	N-α-Allyloxycarbonyl-N-ω-(2,2,4,6,7-pentamethyldihydrobenzofuran-5-sulfonyl)-L-arginine; Fmoc-Arg(Pbf)-OH (common analog); L-Arginine, N2-[(1,1-dimethylethoxy)carbonyl]-N5-[[(2,2,4,6,7-pentamethyldihydrobenzofuran-5-yl)sulfonyl]-; Aloc-Arg(Pbf)-OH; Boc-Arg(Pbf)-OH (common analog); N-α-Alloc-N-ω-Pbf-L-arginine; Protected L-Arginine derivative; Peptide synthesis building block
EINECS	Contact for details

Quality Control

Our Aloc-Arg(Pbf)-Oh is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity, suitable for demanding pharmaceutical research. Each lot undergoes comprehensive analytical testing including HPLC, NMR, and MS for identity and purity confirmation. We provide a detailed Certificate of Analysis (COA) with every shipment, documenting critical parameters such as chiral purity, chemical purity, and residual solvent levels. Our quality commitment aligns with cGMP principles for advanced pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider storing under an inert atmosphere such as argon or nitrogen.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% (L-isomer)
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.