Description

4-Chlorosulfonyl-Piperidine-1-Carboxylic Acid tert-Butyl Ester is a versatile and high-value piperidine-based building block, primarily used as a key intermediate in advanced organic synthesis. Its core value lies in the reactive chlorosulfonyl group, which enables the introduction of sulfonamide functionalities, a critical pharmacophore in modern drug discovery. This compound is essential for research chemists and process development scientists in the pharmaceutical and agrochemical industries, particularly for the synthesis of novel active ingredients targeting a range of therapeutic areas.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of sulfonamide-containing drug candidates, including protease inhibitors, kinase inhibitors, and other small molecule therapeutics.
• Agrochemical Research: Used in the development of novel herbicides, fungicides, and insecticides where the sulfonamide moiety imparts specific biological activity.
• Chemical Biology & Proteomics: Serves as a reagent for synthesizing activity-based probes (ABPs) or affinity tags to study enzyme function and protein interactions.
• Material Science: Potential monomer or cross-linking agent in the development of specialty polymers with unique sulfonyl-based properties.
• Custom Synthesis & Contract Manufacturing: A key starting material for custom synthesis projects requiring the introduction of a protected piperidine-sulfonyl chloride equivalent.

Basic Information

Product Name	4-Chlorosulfonyl-Piperidine-1-Carboxylic Acid tert-Butyl Ester
CAS No.	782501-25-1
Molecular Formula	C10H18ClNO4S
Molecular Weight	283.77 g/mol
Synonyms	1-Boc-4-(chlorosulfonyl)piperidine; tert-Butyl 4-(chlorosulfonyl)piperidine-1-carboxylate; 4-(Chlorosulfonyl)-1-piperidinecarboxylic Acid 1,1-Dimethylethyl Ester; 1-(tert-Butoxycarbonyl)-4-chlorosulfonylpiperidine; N-Boc-4-piperidinesulfonyl chloride; Piperidine-1-carboxylic acid, 4-(chlorosulfonyl)-, 1,1-dimethylethyl ester
EINECS	Contact for details

Quality Control

Our 4-Chlorosulfonyl-Piperidine-1-Carboxylic Acid tert-Butyl Ester is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency suitable for research and scale-up applications. We provide comprehensive Certificates of Analysis (COA) with each batch, detailing purity (typically by HPLC/NMR), identity confirmation, and impurity profiles. Our quality system is designed to support cGMP compliance for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic and moisture-sensitive nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.