Description

tert-Butyl 2,4-Dichloro-5,6,8,9-Tetrahydropyrimido[4,5-D]Azepine-7-Carboxylate is a high-purity, advanced pharmaceutical intermediate with a complex heterocyclic structure. This compound is of significant value in medicinal chemistry for the synthesis of novel drug candidates, particularly those targeting kinase inhibition and other therapeutic pathways. It is primarily required by R&D laboratories and production facilities in the pharmaceutical and biotechnology sectors for process development and scale-up activities.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of active pharmaceutical ingredients (APIs) for oncology and other therapeutic areas.
• Kinase Inhibitor Precursor: Used in research and development of novel kinase inhibitor compounds due to its privileged scaffold.
• Medicinal Chemistry Research: Serves as a versatile core structure for structure-activity relationship (SAR) studies and lead optimization.
• Process Chemistry: Employed in route scouting and scale-up processes for the commercial manufacturing of complex drug molecules.
• Custom Synthesis: Starting material for the contract manufacturing of specialized, high-value chemical entities for clinical trials.

Basic Information

Product Name	tert-Butyl 2,4-Dichloro-5,6,8,9-Tetrahydropyrimido[4,5-D]Azepine-7-Carboxylate
CAS No.	781612-89-3
Molecular Formula	C14H16Cl2N4O2
Molecular Weight	343.21 g/mol
Synonyms	7-tert-Butoxycarbonyl-2,4-dichloro-5,6,8,9-tetrahydropyrimido[4,5-d]azepine; 2,4-Dichloro-7-[(2-methylpropan-2-yl)oxycarbonyl]-5,6,8,9-tetrahydropyrimido[4,5-d]azepine; tert-Butyl 2,4-dichloro-6,7,8,9-tetrahydro-5H-pyrimido[4,5-d]azepine-7-carboxylate; BOC-protected dichloro tetrahydropyrimidoazepine; CAS 781612-89-3
EINECS	Contact for details

Quality Control

Our tert-Butyl 2,4-Dichloro-5,6,8,9-Tetrahydropyrimido[4,5-D]Azepine-7-Carboxylate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) with full traceability are provided to support your regulatory and R&D requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from incompatible materials. For long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.