Description

Benzenemethanamine, 3,4,5-Trifluoro-A-Methyl-, (Ar)- is a high-value, chiral fluorinated benzylamine derivative, a key building block in advanced organic synthesis. Its precise stereochemistry and trifluoromethyl-substituted aromatic ring make it indispensable for creating molecules with enhanced metabolic stability and bioavailability. This compound is primarily sought by pharmaceutical and agrochemical R&D teams for the development of new active ingredients. Its role is critical in constructing complex scaffolds for potential therapeutics and crop protection agents.

Application

• Pharmaceutical Intermediate: A crucial chiral synthon for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and antiviral drug candidates.
• Agrochemical Synthesis: Used in the research and development of advanced herbicides and fungicides, where the fluorine atoms contribute to lipophilicity and membrane permeability.
• Ligand and Catalyst Development: Serves as a precursor for chiral ligands used in asymmetric catalysis, enabling the production of enantiomerically pure compounds.
• Material Science Research: Employed in the synthesis of specialty polymers and advanced organic materials that require fluorinated aromatic components.
• Chemical Biology Probes: Utilized to create labeled compounds and molecular probes for studying biological mechanisms and target engagement.

Basic Information

Item	Detail
Product Name	Benzenemethanamine, 3,4,5-Trifluoro-A-Methyl-, (Ar)-
CAS No.	780743-67-1
Molecular Formula	C8H8F3N
Molecular Weight	175.15 g/mol
Synonyms	(R)-1-(3,4,5-Trifluorophenyl)ethanamine; (R)-α-Methyl-3,4,5-trifluorobenzylamine; (R)-3,4,5-Trifluoro-α-methylbenzylamine; (R)-1-(3,4,5-Trifluorophenyl)ethylamine; (R)-TFMBA; (Ar)-3,4,5-Trifluoro-α-methyl-benzylamine; (R)-1-(3,4,5-Trifluorophenyl)ethan-1-amine
EINECS	Contact for details

Quality Control

Every batch of Benzenemethanamine, 3,4,5-Trifluoro-A-Methyl-, (Ar)- is produced under strict quality management systems. We guarantee high chiral purity and chemical integrity through comprehensive analytical protocols including HPLC, GC, and NMR. A Certificate of Analysis (COA) detailing identity, purity, enantiomeric excess, and impurity profile is provided with each shipment to ensure traceability and compliance with your research or cGMP starting material requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or low-melting solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.