Description

1-(2,3,4-Trifluorophenyl)Ethan-1-Amine is a high-purity fluorinated aromatic amine building block, essential for introducing the 2,3,4-trifluorophenyl pharmacophore into advanced molecular structures. Its primary value lies in enabling the synthesis of novel active pharmaceutical ingredients (APIs) and agrochemicals with enhanced metabolic stability and binding selectivity. This compound is critically needed by R&D and process chemistry teams in the pharmaceutical and agrochemical sectors for developing next-generation therapeutics and crop protection agents.

Application

• Pharmaceutical Intermediate: Key synthon for the development of small molecule drugs, particularly in central nervous system (CNS) and oncology research pipelines.
• Agrochemical Synthesis: Building block for novel herbicides, fungicides, and insecticides, leveraging fluorine's effects on bioavailability and environmental persistence.
• Ligand & Catalyst Development: Used in the preparation of specialized ligands for asymmetric catalysis and metal-organic frameworks (MOFs).
• Material Science Research: Precursor for fluorinated polymers and advanced organic electronic materials requiring specific electron-withdrawing properties.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for scale-up and commercial production of client molecules.

Basic Information

Product Name	1-(2,3,4-Trifluorophenyl)Ethan-1-Amine
CAS No.	780027-85-2
Molecular Formula	C8H7F3N
Molecular Weight	177.14 g/mol
Synonyms	1-(2,3,4-Trifluorophenyl)ethanamine; α-Methyl-2,3,4-trifluorobenzeneethanamine; 1-(2,3,4-Trifluorophenyl)ethylamine; 2,3,4-Trifluoro-α-methylbenzeneethanamine; 1-Aminoethyl-2,3,4-trifluorobenzene; (2,3,4-Trifluorophenyl)ethylamine; 780027-85-2; TFPEA
EINECS	Contact for details

Quality Control

Every batch of 1-(2,3,4-Trifluorophenyl)Ethan-1-Amine is manufactured under cGMP guidelines and undergoes rigorous analytical testing to ensure identity, purity, and consistency. Our quality management system is designed to meet the stringent requirements of pharmaceutical and agrochemical customers. A comprehensive Certificate of Analysis (COA) detailing purity (typically >97% by HPLC), residual solvents, and other critical parameters is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flames. The container should be kept tightly sealed to minimize exposure to moisture and atmospheric carbon dioxide.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Individual impurity ≤ 1.0%
Total Impurities	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.