Description

n-(2-Hydroxyethyl)-4-(6-(4-(Trifluoromethoxy)Phenylamino)Pyrimidin-4-Yl)Benzamide is a high-purity, advanced pharmaceutical intermediate with a complex heterocyclic structure. This compound is critical for research and development in medicinal chemistry, particularly in the synthesis of targeted therapeutic agents. It is primarily sought by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in developing novel small-molecule drugs.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel active pharmaceutical ingredients (APIs) targeting specific disease pathways.
• Kinase Inhibitor Research: Serves as a core scaffold or precursor in the development of protein kinase inhibitors for oncology and inflammatory diseases.
• Medicinal Chemistry & Lead Optimization: Used in structure-activity relationship (SAR) studies to optimize drug candidate potency, selectivity, and pharmacokinetic properties.
• Biochemical Research: Employed as a tool compound or reference standard in biochemical assays to study enzyme function and cellular signaling.
• Contract Research & Development (CRO/CMO): Supplied to organizations specializing in custom synthesis and process development for the pharmaceutical industry.
• Academic Research: Utilized in university and institutional labs for fundamental research in organic synthesis and drug discovery.

Basic Information

Product Name	n-(2-Hydroxyethyl)-4-(6-(4-(Trifluoromethoxy)Phenylamino)Pyrimidin-4-Yl)Benzamide
CAS No.	778274-97-8
Molecular Formula	C20H18F3N5O3
Molecular Weight	433.38 g/mol
Synonyms	4-[6-[[4-(Trifluoromethoxy)phenyl]amino]pyrimidin-4-yl]-N-(2-hydroxyethyl)benzamide; N-(2-Hydroxyethyl)-4-[6-[[4-(trifluoromethoxy)phenyl]amino]-4-pyrimidinyl]benzamide; 778274-97-8; UNII-9J8H2V6H4I; 9J8H2V6H4I; Benzamide, N-(2-hydroxyethyl)-4-[6-[[4-(trifluoromethoxy)phenyl]amino]-4-pyrimidinyl]-; BDBM50164985; AKOS025147064
EINECS	Contact for details

Quality Control

Our n-(2-Hydroxyethyl)-4-(6-(4-(Trifluoromethoxy)Phenylamino)Pyrimidin-4-Yl)Benzamide is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. A Certificate of Analysis (COA) detailing all specifications and test results is provided to ensure traceability and compliance with your research or cGMP-grade requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation from atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.