Description

Fmoc-D,L-5,5,5-Trifluoroleucine CAS NO 777946-04-0 is a non-natural, fluorinated amino acid derivative protected with a 9-fluorenylmethoxycarbonyl (Fmoc) group. This compound is a critical building block in solid-phase peptide synthesis (SPPS), where the fluorine atoms and the branched side chain are strategically introduced to modulate the peptide's metabolic stability, lipophilicity, and three-dimensional structure. It is primarily utilized by research scientists and process chemists in the pharmaceutical and biotechnology sectors for the development of novel therapeutic peptides, peptidomimetics, and bioactive probes.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected amino acid for the automated synthesis of fluorinated peptides, enhancing resistance to enzymatic degradation.
• Pharmaceutical Research & Development: Used to incorporate trifluoromethyl groups into peptide backbones to improve drug-like properties such as membrane permeability and metabolic stability.
• Medicinal Chemistry: Serves as a building block for creating peptide-based drug candidates and libraries for high-throughput screening.
• Chemical Biology: Employed in the synthesis of labeled or modified peptides for studying protein-protein interactions and biological pathways.
• Agrochemical Research: Potential use in the design of bioactive peptides with enhanced properties for crop protection agents.
• Material Science: Exploration of fluorinated peptides for creating novel biomaterials with unique surface properties.

Basic Information

Product Name	Fmoc-D,L-5,5,5-Trifluoroleucine
CAS No.	777946-04-0
Molecular Formula	C₂₂H₂₂F₃NO₄
Molecular Weight	421.41 g/mol
Synonyms	Fmoc-5,5,5-trifluoroleucine; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-5,5,5-trifluoroleucine; Fmoc-Tle(CF3)-OH; N-Fmoc-5,5,5-trifluoro-DL-leucine; 2-[[(9H-Fluoren-9-ylmethoxy)carbonyl]amino]-4,4,4-trifluoro-3-methylbutanoic acid; 5,5,5-Trifluoro-DL-leucine N-Fmoc derivative; Fmoc-DL-5,5,5-Trifluoroleucine; N-α-Fmoc-5,5,5-trifluoroleucine
EINECS	Contact for details

Quality Control

Our Fmoc-D,L-5,5,5-Trifluoroleucine is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency suitable for sensitive research and development applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry standards for fine chemicals and can provide material tailored to specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.