Description

N,n-Dimethyl-4-Piperazin-1-Ylpyrimidin-2-Amine is a high-purity, advanced pharmaceutical intermediate characterized by its piperazine-pyrimidine core structure. This compound is of significant commercial interest for its role in the synthesis of novel, biologically active molecules, particularly in medicinal chemistry. It is primarily sought by research institutions and pharmaceutical manufacturers engaged in the development of new therapeutic agents, including kinase inhibitors and other targeted small-molecule drugs.

Application

• Pharmaceutical Intermediate: A key building block in the research and development of new drug candidates, especially for oncology and CNS disorders.
• Kinase Inhibitor Synthesis: Used in the preparation of potent and selective kinase inhibitors, a major class of targeted cancer therapies.
• Medicinal Chemistry Research: Serves as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Biochemical Tool Compound: Employed in biochemical assays to study enzyme function and cellular signaling pathways.
• Contract Manufacturing (CMO): Supplied to contract manufacturing organizations for the cGMP production of active pharmaceutical ingredients (APIs).
• Academic Research: Utilized in university and institutional labs for fundamental research in organic synthesis and chemical biology.

Basic Information

Product Name	N,n-Dimethyl-4-Piperazin-1-Ylpyrimidin-2-Amine
CAS No.	777807-92-8
Molecular Formula	C11H18N6
Molecular Weight	234.31 g/mol
Synonyms	4-(Piperazin-1-yl)-N,N-dimethylpyrimidin-2-amine; 2-Pyrimidinamine, N,N-dimethyl-4-(1-piperazinyl)-; N,N-Dimethyl-4-(piperazin-1-yl)pyrimidin-2-amine; 777807-92-8; N,N-Dimethyl-4-piperazin-1-yl-pyrimidin-2-ylamine; 4-(1-Piperazinyl)-N,N-dimethyl-2-pyrimidinamine
EINECS	Contact for details

Quality Control

Every batch of N,n-Dimethyl-4-Piperazin-1-Ylpyrimidin-2-Amine is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the high-purity standards required for pharmaceutical research and development. A detailed Certificate of Analysis (COA) is supplied with each shipment, confirming identity, purity (typically ≥95% by HPLC), and impurity profile.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to minimize exposure to atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.