Description

L-Norleucine, 4,5-Dimethyl-, (4S)- (9Ci) is a high-purity, non-proteinogenic amino acid derivative characterized by its specific stereochemistry and alkyl side chain modifications. This compound is of significant value in advanced organic synthesis and pharmaceutical research, serving as a crucial chiral building block for the development of novel bioactive molecules. It is primarily needed by research institutions and pharmaceutical companies engaged in peptide chemistry, medicinal chemistry, and the synthesis of complex natural products.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new active pharmaceutical ingredients (APIs), particularly for peptide-based therapeutics.
• Peptide Synthesis: Used to incorporate modified norleucine residues into custom peptides to study structure-activity relationships (SAR) and enhance metabolic stability.
• Medicinal Chemistry Research: Employed as a building block for creating compound libraries to screen for novel biological activity in drug discovery programs.
• Biochemical Research: Utilized in enzymatic studies and as a non-natural amino acid analog in metabolic pathway investigations.
• Agrochemical Development: Potential application as an intermediate in the synthesis of specialized, chiral agrochemicals.

Basic Information

Product Name	L-Norleucine, 4,5-Dimethyl-, (4S)- (9Ci)
CAS No.	775275-02-0
Molecular Formula	C8H17NO2
Molecular Weight	159.23 g/mol
Synonyms	(2S)-2-Amino-4,5-dimethylhexanoic acid; (S)-2-Amino-4,5-dimethylhexanoic acid; L-4,5-Dimethylnorleucine; (4S)-4,5-Dimethyl-L-norleucine; 4,5-Dimethyl-L-norleucine; 4,5-Dimethylnorleucine; L-2-Amino-4,5-dimethylhexanoic acid
EINECS	Contact for details

Quality Control

Our L-Norleucine, 4,5-Dimethyl-, (4S)- (9Ci) is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for research and development applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and chiral excess is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (typically 15-25°C). This material is hygroscopic (moisture-sensitive); keep the container tightly sealed to prevent absorption of atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.