Description

2,4(1H,3H)-Pyrimidinedione, 5-[(2R,5S)-5-(Hydroxymethyl)-2-Pyrrolidinyl]- (9Ci) is a high-purity, chiral pyrimidine derivative of significant interest in advanced organic synthesis. This compound serves as a critical pharmaceutical intermediate and a versatile building block for the development of novel active pharmaceutical ingredients (APIs). It is primarily utilized by research institutions and manufacturers in the pharmaceutical, biotechnology, and fine chemical sectors for drug discovery and process development.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the research and synthesis of nucleoside analogs and other therapeutic agents.
• Antiviral Drug Research: Building block in the development of novel antiviral compounds targeting viral polymerases.
• Oncology Research: Used in the synthesis of potential chemotherapeutic agents and targeted cancer therapies.
• Biochemical Research: Serves as a substrate or inhibitor in enzymatic studies and biochemical assays.
• Process Chemistry: Employed in route scouting and scale-up studies for the production of complex molecules under GMP conditions.
• Academic Research: Utilized in universities and research institutes for methodological development in asymmetric synthesis and medicinal chemistry.

Basic Information

Item	Details
Product Name	2,4(1H,3H)-Pyrimidinedione, 5-[(2R,5S)-5-(Hydroxymethyl)-2-Pyrrolidinyl]- (9Ci)
CAS No.	775270-48-9
Molecular Formula	C9H13N3O3
Molecular Weight	211.22 g/mol
Synonyms	5-[(2R,5S)-5-(Hydroxymethyl)-2-pyrrolidinyl]-2,4(1H,3H)-pyrimidinedione; (2R,5S)-5-(Hydroxymethyl)-2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)pyrrolidine-1-carboxylic acid tert-butyl ester (related protected form); 5-((2R,5S)-5-(Hydroxymethyl)pyrrolidin-2-yl)pyrimidine-2,4(1H,3H)-dione; Chiral Dihydroxypyrimidine Pyrrolidine Derivative; Nucleoside Analog Intermediate; CAS 775270-48-9
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to stringent quality systems suitable for GMP and ICH Q7 guidelines. Every batch is characterized using advanced analytical techniques including HPLC, chiral HPLC, NMR, and MS to ensure identity, purity, and enantiomeric excess. Comprehensive Certificates of Analysis (COA) detailing all specifications and test results are provided with each shipment to guarantee traceability and compliance for your critical research and development projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% e.e.
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.