Description

Histidine, 5-(4-Pyridinylmethyl)- (9Ci) is a specialized, non-proteinogenic amino acid derivative that combines the imidazole side chain of histidine with a pyridinylmethyl moiety. This unique structure makes it a valuable advanced pharmaceutical intermediate and a versatile building block for medicinal chemistry research and development. It is primarily utilized by pharmaceutical R&D teams and fine chemical manufacturers focused on creating novel bioactive compounds, including enzyme inhibitors and receptor modulators.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel drug candidates, particularly those targeting neurological or metabolic pathways.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to develop new pharmacophores and optimize lead compounds.
• Biochemical Tool Compound: Serves as a precursor or analog in the study of histidine-related biochemical processes and enzyme mechanisms.
• Peptidomimetic Synthesis: Incorporated into peptide analogs to enhance stability, bioavailability, or receptor binding affinity.
• Ligand Development: Utilized in the creation of chelating agents or catalysts due to the potential metal-coordinating properties of its functional groups.

Basic Information

Product Name	Histidine, 5-(4-Pyridinylmethyl)- (9Ci)
CAS No.	774529-58-7
Molecular Formula	C14H16N4O2
Molecular Weight	272.31 g/mol
Synonyms	5-[(Pyridin-4-yl)methyl]-L-histidine; 4-Pyridinylmethylhistidine; L-Histidine, 5-[(4-pyridinyl)methyl]-; (2S)-2-Amino-3-[5-[(pyridin-4-yl)methyl]-1H-imidazol-4-yl]propanoic acid; Histidine derivative, 5-(4-Pyridylmethyl)-; 774529-58-7; 5-(4-Pyridylmethyl)histidine
EINECS	Contact for details

Quality Control

Our Histidine, 5-(4-Pyridinylmethyl)- (9Ci) is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the high standards required for research and development applications. A detailed Certificate of Analysis (COA) is provided with every shipment, guaranteeing traceability and consistent quality.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be kept in a dry environment to maintain stability and purity. For long-term storage, consider desiccants or inert atmosphere conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.