Description

L-Norleucine, 4,5-Dimethyl-, (4R)- (9Ci) is a non-proteinogenic, chiral amino acid derivative characterized by its specific stereochemistry and alkyl-substituted side chain. This compound matters as a high-value building block in advanced organic synthesis and pharmaceutical research, offering precise structural control for developing novel bioactive molecules. It is primarily needed by research chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for applications in asymmetric synthesis, peptide mimetics, and medicinal chemistry.

Application

• Pharmaceutical Intermediate: Serves as a key chiral synthon in the research and development of new active pharmaceutical ingredients (APIs), particularly for metabolic and neurological targets.
• Peptidomimetics & Drug Design: Used to incorporate unnatural amino acid residues into peptide chains to enhance metabolic stability, bioavailability, and receptor selectivity.
• Asymmetric Catalysis: Acts as a precursor for chiral ligands or auxiliaries in enantioselective synthesis, crucial for producing optically pure compounds.
• Agrochemical Research: Employed in the synthesis of novel herbicides, fungicides, or plant growth regulators with specific stereochemical requirements.
• Biochemical Research: Utilized as a substrate or inhibitor in enzymatic studies to investigate metabolic pathways and enzyme mechanisms.
• Material Science: Potential building block for functionalized polymers or supramolecular structures with tailored properties.

Basic Information

Product Name	L-Norleucine, 4,5-Dimethyl-, (4R)- (9Ci)
CAS No.	774172-49-5
Molecular Formula	C8H17NO2
Molecular Weight	159.23 g/mol
Synonyms	(2R)-2-Amino-4,5-dimethylhexanoic acid; (R)-2-Amino-4,5-dimethylhexanoic acid; L-4,5-Dimethylnorleucine; (4R)-4,5-Dimethyl-L-norleucine; 4,5-Dimethylnorleucine; UNII-9V6T7Q6M5C; 9CI L-Norleucine, 4,5-dimethyl-, (4R)-
EINECS	Contact for details

Quality Control

Our L-Norleucine, 4,5-Dimethyl-, (4R)- (9Ci) is produced under a strict quality management system. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for research and development. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and chiral excess is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent absorption of atmospheric moisture, which can affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.