Description

2-Chloro-6-Fluoroquinazolin-4(3H)-One is a high-value, multi-functional heterocyclic building block essential for advanced organic synthesis. Its core quinazolinone scaffold, strategically substituted with chlorine and fluorine atoms, makes it a critical intermediate for developing novel active pharmaceutical ingredients (APIs) and agrochemicals. This compound is primarily sought by research and development teams in the pharmaceutical, agrochemical, and specialty chemical industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of tyrosine kinase inhibitors (TKIs) and other targeted cancer therapies.
• Agrochemical Research: Used in developing new generations of herbicides and fungicides, leveraging the bioactivity of the quinazolinone core.
• Chemical Biology Probe: Serves as a scaffold for creating tool compounds to study enzyme function and signal transduction pathways.
• Material Science: Investigated as a building block for organic electronic materials and advanced polymers due to its fused aromatic structure.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs for the production of client-specific novel chemical entities (NCEs).

Basic Information

Product Name	2-Chloro-6-Fluoroquinazolin-4(3H)-One
CAS No.	769158-12-5
Molecular Formula	C₈H₄ClFN₂O
Molecular Weight	198.58 g/mol
Synonyms	2-Chloro-6-fluoro-3,4-dihydro-4-oxoquinazoline; 2-Chloro-6-fluoro-4(3H)-quinazolinone; 4(3H)-Quinazolinone, 2-chloro-6-fluoro-; 6-Fluoro-2-chloroquinazolin-4(3H)-one; 769158-12-5; 2-Chloro-6-fluoroquinazolin-4-ol; 2-Chloro-6-fluoro-4-hydroxyquinazoline
EINECS	Contact for details

Quality Control

Our 2-Chloro-6-Fluoroquinazolin-4(3H)-One is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with every shipment, confirming compliance with customer specifications and supporting regulatory filings for research and development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong bases and oxidizing agents. For long-term storage, consider inert atmosphere conditions to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.