Description

4-Chloro-6-Cyclobutylpyrimidine is a high-value pyrimidine derivative, a crucial heterocyclic building block in advanced organic synthesis. Its core value lies in its bifunctional reactivity, where the chloro substituent serves as an excellent leaving group for nucleophilic aromatic substitution, and the cyclobutyl ring offers unique steric and electronic properties for modulating molecular architecture. This compound is essential for research chemists and process development scientists in the pharmaceutical and agrochemical industries, particularly for constructing novel active ingredients and exploring structure-activity relationships.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of kinase inhibitors, antiviral agents, and other small-molecule drug candidates.
• Agrochemical Research: Used in the development of novel herbicides, fungicides, and plant growth regulators.
• Material Science: Serves as a monomer or functional unit in the creation of specialty polymers and organic electronic materials.
• Chemical Biology: Employed as a probe or linker in the design of biochemical tools and molecular tags.
• Academic & Contract Research: A versatile scaffold for methodological development in organic chemistry and medicinal chemistry programs.

Basic Information

Product Name	4-Chloro-6-Cyclobutylpyrimidine
CAS No.	768397-43-9
Molecular Formula	C8H9ClN2
Molecular Weight	168.62 g/mol
Synonyms	4-Chloro-6-cyclobutylpyrimidine; 6-Cyclobutyl-4-chloropyrimidine; Pyrimidine, 4-chloro-6-cyclobutyl-; 4-Chloro-6-cyclobutyl-pyrimidine; 768397-43-9
EINECS	Contact for details

Quality Control

Our 4-Chloro-6-Cyclobutylpyrimidine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and GC for residual solvent analysis, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) detailing all specifications are provided with every shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.