Description

7-(Benzyloxy)-n-(4-Bromo-2-Fluorophenyl)-6-Methoxyquinazolin-4-Amine is a high-purity, advanced pharmaceutical intermediate designed for precision synthesis. This compound matters because it serves as a critical building block in the development of targeted small-molecule therapeutics, particularly kinase inhibitors. Pharmaceutical R&D teams and fine chemical manufacturers need this material for its role in creating novel drug candidates with potential applications in oncology and other disease areas.

Application

• Pharmaceutical Intermediate: A key precursor in the multi-step synthesis of targeted kinase inhibitors for oncology research.
• Chemical Biology Probe Development: Used to create tool compounds for studying specific enzyme pathways and cellular signaling mechanisms.
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies to optimize drug candidate potency and selectivity.
• Contract Development and Manufacturing (CDMO): Supplied to CDMOs for the cGMP production of active pharmaceutical ingredients (APIs) under development.
• Academic Research: Utilized in university and institutional labs for foundational research in drug discovery and chemical synthesis methodologies.

Basic Information

Product Name	7-(Benzyloxy)-n-(4-Bromo-2-Fluorophenyl)-6-Methoxyquinazolin-4-Amine
CAS No.	768350-54-5
Molecular Formula	C22H17BrFN3O2
Molecular Weight	454.29 g/mol
Synonyms	7-(Benzyloxy)-N-(4-bromo-2-fluorophenyl)-6-methoxyquinazolin-4-amine; 4-Amino-7-(benzyloxy)-N-(4-bromo-2-fluorophenyl)-6-methoxyquinazoline; 768350-54-5; 7-Benzyloxy-N-(4-bromo-2-fluorophenyl)-6-methoxy-4-quinazolinamine; 4-Quinazolinamine, 7-(benzyloxy)-N-(4-bromo-2-fluorophenyl)-6-methoxy-; N-(4-Bromo-2-fluorophenyl)-7-(benzyloxy)-6-methoxyquinazolin-4-amine
EINECS	Contact for details

Quality Control

Our 7-(Benzyloxy)-n-(4-Bromo-2-Fluorophenyl)-6-Methoxyquinazolin-4-Amine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the exacting standards required for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing purity, impurities, and full analytical data is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). The compound is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Related Substances (HPLC)	Individual impurity ≤ 1.0%
Total Impurities	≤ 3.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.